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Art. -Nr.: HY-120808

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GSK2188764

GSK2188764 is a Toxoplasma gondii rhoptry protein 18 (ROP18) inhibitor with reported IC₅₀ values of 7.49 μM against Toxoplasma gondii. GSK2188764 inhibits serine-threonine kinase activity of ROP18 in vitro.GSK2188764 can be used for the research of toxoplasmosis.

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CAS. Nr.: 1849587-68-3
Formel: C₁₇H₁₆Cl₂N₆O
Molecular Weight:391.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

GSK2188764 Chemical Structure

CAS. Nr.: 1849587-68-3

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Biologische Aktivität
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Beschreibung

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In Vitro

GSK2188764 (up to 10 μM; 10 min pre-incubation, 3 h reaction) weakly inhibits recombinant Toxoplasma gondii ROP18 kinase activity in vitro, with an IC₅₀ of 7.49 μM against the FL-E substrate and >10 μM against the FL-T and FL-8 substrates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1849587-68-3
Molecular Weight 391.26
Formel C₁₇H₁₆Cl₂N₆O
SMILES

O=C1NC=CC=2N=C(N=C(NC=3C=C(Cl)C=C(Cl)C3)C12)NC4CNCC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Simpson C,et al. Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18. ACS Infect Dis. 2016 Mar 11;2(3):194-206.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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GSK2188764

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GSK2188764 Related Classifications

HY-120808 Related Classifications