KRAS-IN-51
KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor, with its IC50 for KRas G12V being 2.9 nM; KD values are 17 (at 20°C) and 68 (at 37°C) nM. KRAS-IN-51 inhibits the phosphorylation of pERK. KRAS-IN-51 has anti-proliferative activity against SW620 and MIAPaCa-2. KRAS-IN-51 can be used for research on colorectal cancer and pancreatic cancer.
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- CAS. Nr.: 3076211-50-9
- Formel: C31H39FN6O3
- Molecular Weight:562.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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KRas G12V 2.9 nM (IC50) |
Chemical Information
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CAS. Nr. 3076211-50-9
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Molecular Weight 562.68
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Formel C31H39FN6O3
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SMILES
N#CC1=C2[C@]3(CC[C@@H](C2=CC=C1N)C)CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7[C@](C)(CC7)CO)=C4CO3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KRAS-IN-51 Related Classifications
HY-186024 Related Classifications
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