3076211-50-9
3076211-50-9
Chemical Structure
KRAS-IN-51
- CAS No.: 3076211-50-9
- Formula:C31H39FN6O3
- Molecular Weight:562.68
InChIKey: HRTYKBHLPJAKIA-ANECNKCISA-N
SMILES: N#CC1=C2[C@]3(CC[C@@H](C2=CC=C1N)C)CC4=NC(OC[C@@]56N(CCC6)C[C@@H](C5)F)=NC(N7[C@](C)(CC7)CO)=C4CO3
Biological Activity: KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor, with its IC50 for KRas G12V being 2.9 nM; KD values are 17 (at 20°C) and 68 (at 37°C) nM. KRAS-IN-51 inhibits the phosphorylation of pERK. KRAS-IN-51 has anti-proliferative activity against SW620 and MIAPaCa-2. KRAS-IN-51 can be used for research on colorectal cancer and pancreatic cancer[1].
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KRAS-IN-51 | KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor, with its IC50 for KRas G12V being 2.9 nM; KD values are 17 (at 20°C) and 68 (at 37°C) nM. KRAS-IN-51 inhibits the phosphorylation of pERK. KRAS-IN-51 has anti-proliferative activity against SW620 and MIAPaCa-2. KRAS-IN-51 can be used for research on colorectal cancer and pancreatic cancer. | |||||||||||||||||||||
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References
Keywords
