Ttyh1 - tweety family member 1 Gene

Also Known as tty; TTY1; mTTY1; 4930459B04Rik; 6330408P11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 57776

Summary

This gene encodes a member of the Tweety family of membrane proteins. Members of this family contain five predicted transmembrane regions that are arranged in a characteristic pattern. In mouse, the protein is predominantly localized to the endoplasmic reticulum and displays calcium binding activity. Targeted knock out of this gene results in early embryonic lethality prior to the blastocyst stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Ttyh1 Products (4)

mRNA	Protein	Name
NM_001001454.4	NP_001001454.2	protein tweety homolog 1 isoform 1
NM_001109765.2	NP_001103235.1	protein tweety homolog 1 isoform 2
NM_001305822.1	NP_001292751.1	protein tweety homolog 1 isoform 3
NM_021324.6	NP_067299.2	protein tweety homolog 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	20634317	MGI
enables volume-sensitive chloride channel activity	IDA IDA: Inferred from direct assay	31138989	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	31138989	MGI
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	31079925	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	31079925	MGI
acts upstream of or within cell-cell adhesion	IDA IDA: Inferred from direct assay	17116230	MGI
acts upstream of or within cell-substrate adhesion	IDA IDA: Inferred from direct assay	17116230	MGI
acts upstream of or within filopodium assembly	IDA IDA: Inferred from direct assay	17116230	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	31079925	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20568244	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	31079925	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	31079925	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	31079925	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in filopodium membrane	IDA IDA: Inferred from direct assay	17116230	MGI
located in filopodium tip	IDA IDA: Inferred from direct assay	17116230	MGI
is active in membrane	IDA IDA: Inferred from direct assay	31079925	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	31138989	MGI
located in smooth endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	20568244	MGI
is active in synapse	EXP EXP: Inferred from Experiment	16635246	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16635246	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein tweety homolog 1	tweety homolog 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15241	TTYH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttyh1	NCBI	NCBI:57348