CGS 18320B
CGS 18320B is a human placental microsomal aromatase inhibitor with a Ki of 0.16 nM. CGS 18320B interacts reversibly with the enzyme's active site to block estrogen biosynthesis from androstenedione. CGS 18320B can be used for the research of aromatase inhibition and estrogen biosynthesis regulation.
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- CAS No.: 112808-99-8
- Formule: C22H18N4O4
- Masse moléculaire:402.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Aromatase 0.16 nM (Ki) |
CGS 18320B (0.15 nM, 0.4 nM, 1.0 nM; 2 min preincubation, 5 min reaction) competitively inhibits human placental microsomal aromatase with an apparent Ki of 0.16 nM[1].
CGS 18320B (0.17 nM, 0.5 nM, 1.7 nM, 8.4 nM; 0, 10, 20, 30 min preincubation, 10 min substrate incubation) reversibly inhibits human placental microsomal aromatase, with no time-dependent increase in inhibitory effect observed over 30 minutes of preincubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 112808-99-8
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Masse moléculaire 402.40
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Formule C22H18N4O4
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SMILES
N#CC1=CC=C(C(N2C=NC=C2)C3=CC=C(C=C3)C#N)C=C1.O=C(CCC(O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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