DCC - DCC netrin 1 receptor Gene

Also Known as CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1630

About DCC

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:52,340,197-53,535,899 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues, 36 paralogues and is associated with 109 phenotypes. Biased expression in testis (RPKM 2.4), brain (RPKM 1.4) and 2 other tissues.

Summary

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces Apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal Cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

DCC Products (1)

mRNA	Protein	Name
NM_005215.4	NP_005206.2	netrin receptor DCC

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11527412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCC Protein Structure

Ig_2

I-set

fn3

Neogenin_C

0
300
600
900
1200
1447 a.a.

Protein Preferred Names	Protein Names
netrin receptor DCC	colorectal cancer suppressor

DCC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	DCC	P43146	MAZ	Homo sapiens	P56270	Y2H	11527412
Intra	DCC	P43146	MAZ	Homo sapiens	P56270	Pull Down	11527412
Intra	DCC	P43146	NTN1	Homo sapiens	O95631	AVEXIS	26190107
Intra	DCC	P43146	NTN1	Homo sapiens	O95631	Solid Phase Assay	19721007
Intra	DCC	P43146	NTN1	Homo sapiens	O95631	Anti Bait CoIP	20434207
Intra	DCC	P43146	MYO10	Homo sapiens	Q9HD67	X-Ray Diffraction	21642953
Intra	DCC	P43146	MYO10	Homo sapiens	Q9HD67	Pull Down	21642953
Intra	DCC	P43146	MYO10	Homo sapiens	Q9HD67	ITC	21642953
Intra	DCC	P43146	RPS23	Homo sapiens	P62266	Density Sedimentation	20434207
Intra	DCC	P43146	RPL5	Homo sapiens	P46777	Density Sedimentation	20434207
Intra	DCC	P43146	RPL5	Homo sapiens	P46777	Anti Bait CoIP	20434207
Intra	DCC	P43146	RPL28	Homo sapiens	P46779	Anti Bait CoIP	20434207
Intra	DCC	P43146	CASP9	Homo sapiens	P55211	Anti Tag CoIP	16537496

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCC Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P78745	Netrin receptor DCC/DCC Protein, Human (HEK293, His)	P43146 (F32-N1097)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78754	Netrin receptor DCC/DCC Protein, Human (HEK293, Fc)	P43146 (F32-N1097)	≥ 90%, as determined by reducing SDS-PAGE.

DCC Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P86845	DCC Antibody (YA6538)	WB, IHC-F	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mirror Movements 1	Congenital Mirror Movement Disorder Bimanual Synergia Congenital Mirror Movements Familial Congenital Controlateral Synkinesia Familial Congenital Mirror Movements Hereditary Congenital Controlateral Synkinesia Hereditary Congenital Mirror Movements Isolated Congenital Controlateral Synkinesia Isolated Congenital Mirror Movements Mirror Movements MRMV1 Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum Mirror Movements, Congenital Bimanual Synkinesis Cmm Mirror Movements, Type 1
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development	Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 HGPPS2 Developmental Split-Brain Syndrome Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2, With Impaired Intellectual Development
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 1	Hgpps Horizontal Gaze Palsy With Progressive Scoliosis Gaze Palsy, Familial Horizontal, With Progressive Scoliosis HGPPS1 Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 1 Gaze Palsy, Horizontal, With Progressive Scoliosis Progressive External Ophthalmoplegia And Scoliosis Familial Horizontal Gaze Palsy With Progressive Scoliosis Familial Idiopathic Scoliosis Associated With Congenital Encephalopathy Familial Infantile Scoliosis Associated With Bilateral Paralysis Of Conjugate Gaze Ophthalmoplegia, Progressive External, And Scoliosis Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, Type 1
Corpus Callosum, Agenesis Of	Corpus Callosum Agenesis Agenesis Of The Corpus Callosum Isolated Corpus Callosum Agenesis Acc Non Rare In Europe: Isolated Corpus Callosum Agenesis Congenital Malformation Of Corpus Callosum Deformity Of Corpus Callosum Absence Of Corpus Callosum Absent Corpus Callosum Acc - [Agenesis Of Corpus Callosum] Aplasia Of Corpus Callosum Congenital Absence Of Corpus Callosum Hypoplastic Corpus Callosum Hypoplasia Of Corpus Callosum
Intellectual Disability - Hypoplastic Corpus Callosum - Preauricular Tag	Da Silva Syndrome Intellectual Disability-Hypoplastic Corpus Callosum-Preauricular Tag Syndrome
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Corpus Callosum, Partial Agenesis Of, X-Linked	X-Linked Complicated Corpus Callosum Dysgenesis Corpus Callosum, Partial Agenesis Of Partial Agenesis Of The Corpus Callosum Partial Agenesis Of Corpus Callosum Agenesis Of The Corpus Callosum, X-Linked, Partial ACCPX Agenesis, Corpus Callosum, Partial
Non-Syndromic X-Linked Intellectual Disability Arx-Related	Arx-Related Intellectual Disability Mrxarx X-Linked Mental Retardation 29 X-Linked Mental Retardation 29 And Others X-Linked Mental Retardation 32 X-Linked Mental Retardation 33 X-Linked Mental Retardation 38 X-Linked Mental Retardation 43 X-Linked Mental Retardation 76 X-Linked Mental Retardation 87 X-Linked Mental Retardation With Or Without Seizures Arx-Related Mental Retardation, X-Linked, Type 29 And Others
Scoliosis
Gastric Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Stomach Squamous Cell Carcinoma Of The Stomach
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-112306	Ripretinib		98.90%	Yes
HY-136256	Vimseltinib	Inhibitor	99.94%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-13024	Rebastinib		99.84%	Phase 2
HY-160699	DCC-3116	Inhibitor	99.84%	Phase 2
HY-B0791	Altiratinib	Inhibitor	99.29%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-Y1092	N,N-Dicyclohexylcarbodiimide(DCC)	Activator	99.75%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.84%	Unkown
HY-W099632	2-Hexyldecanoic acid		99.71%	Unkown
HY-D2751	BP Fluor 488 cadaverine		98.15%	Unkown
HY-100855	DC_C66	Inhibitor	/	Unkown
HY-13024A	Rebastinib tosylate		/	Unkown
HY-163008	Dicamba-5-aminopentanoic acid		/	Unkown
HY-RS03571	DCC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157262	Methyl isonicotinate-(CH2)2-COOH		/	Unkown
HY-D2764	Difluorocarboxyfluorescein cadaverine, 5-isomer		/	Unkown
HY-D2765	BP Fluor 405 cadaverine		/	Unkown
HY-D2772	5-TAMRA Cadaverine		/	Unkown
HY-RS17183	Dcc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23634	Dcc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCC	VGNC	VGNC:61363
Mus musculus	DCC	MGD	MGI:94869
Canis familiaris	DCC	VGNC	VGNC:39799
Macaca mulatta	DCC	VGNC	VGNC:71746
Bos taurus	DCC	VGNC	VGNC:109406
Rattus norvegicus	DCC	RGD	RGD:2492
Others	DCC	NCBI