MYO10 - myosin X Gene

Also Known as MyoX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4651

About MYO10

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:16,661,907-16,936,288 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 43 paralogues. Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues.

Summary

This gene encodes a member of the Myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

MYO10 Products (1)

mRNA Protein Name
NM_012334.3 NP_036466.2 unconventional myosin-X

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18570893 GOA
enables spectrin binding IDA
IDA: Inferred from direct assay
23704327 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
16894163 GOA
involved in regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
16894163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO10 Protein Structure

Myosin_head

Myosin_head: Myosin head (motor domain) (65 - 727)

IQ

IQ: IQ calmodulin-binding motif (744 - 763)

IQ

IQ: IQ calmodulin-binding motif (768 - 785)

IQ

IQ: IQ calmodulin-binding motif (790 - 809)

PH

PH: PH domain (1215 - 1308)

PH

PH: PH domain (1395 - 1496)

MyTH4

MyTH4: MyTH4 domain (1584 - 1694)

FERM_M

FERM_M: FERM central domain (1798 - 1958)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2058 a.a.
Protein Preferred Names Protein Names

unconventional myosin-X

  • unconventional myosin-10

MYO10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYO10 Q9HD67 DCC Homo sapiens P43146
Anti Tag CoIP
21642953
Intra
MYO10 Q9HD67 CALML3 Homo sapiens P27482
Fluorescence Spectr
18570893
Intra
MYO10 Q9HD67 CALML3 Homo sapiens P27482
Pull Down
18570893
Cross
MYO10 Q9HD67 Dcc Rattus norvegicus Q63155
Pull Down
21321230
Cross
MYO10 Q9HD67 Dcc Rattus norvegicus Q63155
ITC
21321230
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly

  • MRD44

  • Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome

  • Autosomal Dominant Non-Syndromic Intellectual Disability 44

  • Mental Retardation, Autosomal Dominant 44

  • Autosomal Dominant Intellectual Developmental Disorder 44

  • Autosomal Dominant Intellectual Developmental Disorder 44 With Microcephaly

  • Autosomal Dominant Mental Retardation 44

  • Mental Retardation, Autosomal Dominant, Type 44
Chondrocalcinosis

  • Pseudogout

  • Calcium Pyrophosphate Deposition Disease

  • Familial Chondrocalcinosis

  • Chondrocalcinosis Nos

  • Cppd - [Calcium Pyrophosphate Deposition Disease]

  • Cpdd - [Calcium Pyrophosphate Deposition Disease]

  • Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site

  • Chondrocalcinosis, Cause Unspecified

  • Chondrocalcinosis Due To Pyrophosphate Crystals

  • Chondrocalcinosis Articularis

  • Calcium Pyrophosphate Arthritis And Periarthritis
Anterior Segment Dysgenesis 5

  • Anterior Segment Dysgenesis 5, Multiple Subtypes

  • ASGD5

  • Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Achondrogenesis, Type Ib

  • ACG1B

  • Achondrogenesis Type Ib

  • Achondrogenesis Type 1b

  • Achondrogenesis Ib

  • Achondrogenesis Fraccaro Type

  • Achondrogenesis, Fraccaro Type

  • Achondrogenesis, Parenti-Fraccaro Type

  • Achondrogenesis 1b

  • Acg-Ib

  • Fraccaro Achondrogenesis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08930 MYO10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MYO10 VGNC VGNC:31811
Canis familiaris MYO10 VGNC VGNC:43554
Mus musculus MYO10 MGD MGI:107716
Rattus norvegicus MYO10 RGD RGD:1307193
Felis catus MYO10 VGNC VGNC:68387
Macaca mulatta MYO10 VGNC VGNC:75108
Others MYO10 NCBI