NLRC5 - NLR family CARD domain containing 5 Gene

Also Known as NOD4; NOD27; CLR16.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84166

About NLRC5

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,989,557-57,083,520 (from NCBI)

This gene has 29 transcripts (splice variants), 169 orthologues and 20 paralogues. Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues.

Summary

This gene encodes a member of the Caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and Antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

NLRC5 Products (26)

mRNA Protein Name
NM_001330552.2 NP_001317481.1 protein NLRC5 isoform 2
NM_001384950.1 NP_001371879.1 protein NLRC5 isoform 1
NM_001384951.1 NP_001371880.1 protein NLRC5 isoform 2
NM_001384952.1 NP_001371881.1 protein NLRC5 isoform 3
NM_001384953.1 NP_001371882.1 protein NLRC5 isoform 3
NM_001384954.1 NP_001371883.1 protein NLRC5 isoform 4
NM_001384955.1 NP_001371884.1 protein NLRC5 isoform 5
NM_001384956.1 NP_001371885.1 protein NLRC5 isoform 6
NM_001384957.1 NP_001371886.1 protein NLRC5 isoform 7
NM_001384958.1 NP_001371887.1 protein NLRC5 isoform 8
NM_001384959.1 NP_001371888.1 protein NLRC5 isoform 9
NM_001384960.1 NP_001371889.1 protein NLRC5 isoform 10
NM_001384961.1 NP_001371890.1 protein NLRC5 isoform 11
NM_001384962.1 NP_001371891.1 protein NLRC5 isoform 11
NM_001384963.1 NP_001371892.1 protein NLRC5 isoform 12
NM_001384964.1 NP_001371893.1 protein NLRC5 isoform 12
NM_001384965.1 NP_001371894.1 protein NLRC5 isoform 13
NM_001384966.1 NP_001371895.1 protein NLRC5 isoform 14
NM_001384967.1 NP_001371896.1 protein NLRC5 isoform 15
NM_001384968.1 NP_001371897.1 protein NLRC5 isoform 16
NM_001384969.1 NP_001371898.1 protein NLRC5 isoform 17
NM_001384970.1 NP_001371899.1 protein NLRC5 isoform 18
NM_001384971.1 NP_001371900.1 protein NLRC5 isoform 19
NM_001384972.1 NP_001371901.1 protein NLRC5 isoform 20
NM_001384973.1 NP_001371902.1 protein NLRC5 isoform 21
NM_032206.5 NP_115582.4 protein NLRC5 isoform 1
Molecular Function GO Annotation Evidence Références Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20639463 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20434986 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20061403 GOA
located in cytosol IDA
IDA: Inferred from direct assay
20639463 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20639463 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRC5 Protein Structure

NACHT

NACHT: NACHT domain (222 - 382)

LRR_6

LRR_6: Leucine Rich repeat (870 - 891)

LRR_6

LRR_6: Leucine Rich repeat (1008 - 1026)

LRR_6

LRR_6: Leucine Rich repeat (1521 - 1542)

LRR_6

LRR_6: Leucine Rich repeat (1578 - 1599)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (1606 - 1648)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1866 a.a.
Protein Preferred Names Protein Names

protein NLRC5

  • NOD-like receptor C5

Related Diseases

Diseases Alias
Pityriasis Rubra Pilaris
  • PRP

  • Devergie'S Disease

  • Prp - [Pityriasis Rubra Pilaris]

Familial Pityriasis Rubra Pilaris
  • Familial Prp

  • Pityriasis Rubra Pilaris--Familial Type

Bare Lymphocyte Syndrome, Type I
  • Hla Class I Deficiency

  • Mhc Class I Deficiency

  • Bls, Type I

  • Bare Lymphocyte Syndrome Type I

  • Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

  • Blsi

  • Mhc Class 1 Deficiency

  • Major Histocompatibility Complex Class 1 Deficiency

  • Bare Lymphocyte Syndrome 1

  • BLS1

  • Bls I

  • Bls Type I

  • Bl-1

  • Bare Lymphocyte Syndrome Type 1

  • Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

  • Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

  • Bls - [Bare Lymphocyte Syndrome] Nos

Familial Mediterranean Fever
  • Periodic Fever Syndrome

  • FMF

  • Benign Paroxysmal Peritonitis

  • Periodic Disease

  • Recurrent Polyserositis

  • Familial Paroxysmal Polyserositis

  • Periodic Fever

  • Familial Mediterranean Fever, Autosomal Recessive

  • Familial Mediterranean Fever, Ar

  • Polyserositis, Recurrent

  • Polyserositis, Familial Paroxysmal

  • Periodic Peritonitis

  • Mef

  • Reimann Periodic Disease

  • Siegal-Cattan-Mamou Disease

  • Wolff Periodic Disease

  • Benign Recurrent Polyserositis

  • Mediterranean Fever, Familial

  • ARFMF

  • Autosomal Recessive Familial Mediterranean Fever

  • Fever, Mediterranean, Familial, Autosomal Recessive

  • Hereditary Autoinflammatory Diseases

  • Fmf - [Familial Mediterranean Fever]

  • Periodic Polyserositis

  • Periodic Familial Polyserositis

  • Periodic Familial Peritonitis

  • Paroxysmal Polyserositis

  • Hereditary Amyloid Nephropathy

  • Familial Recurrent Polyserositis

  • Familial Non-Neuropathic Amyloidosis

  • Armenian Disease

  • Riemann Periodic Disease

  • Siegal Cattan Mamou Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NLRC5 RGD RGD:1309166
Canis familiaris NLRC5 VGNC VGNC:43844
Felis catus NLRC5 VGNC VGNC:63828
Macaca mulatta NLRC5 VGNC VGNC:75285
Bos taurus NLRC5 VGNC VGNC:32114
Mus musculus NLRC5 MGD MGI:3612191
Others NLRC5 NCBI