Genz-669178
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1254834-91-7
- Formule: C17H14N4OS
- Masse moléculaire:322.38
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Parasite
More
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
53 μM
Compound: 2q
|
Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assay
Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assay
|
[PMID: 24900364] |
Chemical Information
-
CAS No. 1254834-91-7
-
Masse moléculaire 322.38
-
Formule C17H14N4OS
-
SMILES
O=C(NC1CC1)C2=CC=C(S2)N3C4=CC=CC(C#N)=C4N=C3C
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Genz-669178 Related Classifications
HY-120462 Related Classifications
Powered by Bioz