Cdh8 - cadherin 8 Gene

This gene encodes a member of the Cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the Cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]