DCX - doublecortin Gene

Also Known as DC; DBCN; LISX; SCLH; XLIS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1641

About DCX

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,293,779-111,412,192 (from NCBI)

This gene has 12 transcripts (splice variants), 123 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 4.3) and endometrium (RPKM 1.0).

Summary

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

DCX Products (11)

mRNA	Protein	Name
NM_000555.3	NP_000546.2	neuronal migration protein doublecortin isoform a
NM_001195553.2	NP_001182482.1	neuronal migration protein doublecortin isoform d
NM_001369370.1	NP_001356299.1	neuronal migration protein doublecortin isoform d
NM_001369371.1	NP_001356300.1	neuronal migration protein doublecortin isoform b
NM_001369372.1	NP_001356301.1	neuronal migration protein doublecortin isoform e
NM_001369373.1	NP_001356302.1	neuronal migration protein doublecortin isoform f
NM_001369374.1	NP_001356303.1	neuronal migration protein doublecortin isoform f
NM_001410715.1	NP_001397644.1	neuronal migration protein doublecortin isoform g
NM_178151.3	NP_835364.1	neuronal migration protein doublecortin isoform c
NM_178152.3	NP_835365.1	neuronal migration protein doublecortin isoform b
NM_178153.3	NP_835366.1	neuronal migration protein doublecortin isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	14741102	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	27292316	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	14741102	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in neuron migration	IDA IDA: Inferred from direct assay	14741102	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in neuron projection	IDA IDA: Inferred from direct assay	14741102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCX Protein Structure

DCX

0
100
200
300
400
441 a.a.

Protein Preferred Names	Protein Names
neuronal migration protein doublecortin	doublecortex

DCX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCX	O43602	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	DCX	O43602	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	DCX	O43602	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	DCX	O43602	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	DCX	O43602	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	DCX	O43602	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	DCX	O43602	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	25416956
Intra	DCX	O43602	GOLGA2	Homo sapiens	Q08379	Y2H	21516116
Intra	DCX	O43602	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	DCX	O43602	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	DCX	O43602	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	DCX	O43602	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	DCX	O43602	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	DCX	O43602	ZBTB5	Homo sapiens	O15062	Validated Y2H	25416956
Intra	DCX	O43602	ZBTB5	Homo sapiens	O15062	Anti Tag CoIP	33961781
Intra	DCX	O43602	ZBTB5	Homo sapiens	O15062	Y2H Array	25416956
Intra	DCX	O43602	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	25416956
Intra	DCX	O43602	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	31515488
Intra	DCX	O43602	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	DCX	O43602	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	DCX	O43602	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	DCX	O43602	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	DCX	O43602	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	DCX	O43602	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	DCX	O43602	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	DCX	O43602	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	DCX	O43602	IKZF1	Homo sapiens	Q13422	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75282	Doublecortin/DCX Protein, Human (His)	O43602-2 (A45-V150)	≥ 80%, as determined by reducing SDS-PAGE.

DCX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80108	Doublecortin Antibody (YA474)	WB, FC	Human, Mouse, Rat
HY-P83844	Doublecortin Antibody (YA3541)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P83844A	Doublecortin Antibody (YA3541)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P86077	Doublecortin Antibody (YA5769)	WB, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lissencephaly, X-Linked, 1	Lissencephaly Type 1 Due To Doublecortin Gene Mutation Xlis Lissencephaly, X-Linked LISX1 Lissencephaly And Agenesis Of Corpus Callosum Subcortical Laminal Heterotopia, X-Linked X-Linked Lissencephaly 1 X-Linked Lissencephaly Double Cortex Xlis1 Lissencephaly X-Linked Lisx X-Linked Lissencephaly Type 1 Lissencephaly, X-Linked 1 Subcortical Band Heterotopia X-Linked SBHX Sclh Subcortical Laminar Heterotopia Lissencephaly, X-Linked, Type 1 Subcortical Band Heterotopia
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Lissencephaly 1	LIS1 Classic Lissencephaly Ils Subcortical Laminar Heterotopia Lissencephaly Due To Lis1 Mutation Lissencephaly Sequence, Isolated Lissencephaly, Classic Pafah1b1-Related Lissencephaly Classical Lissencephaly Lissencephaly Type 1 Lissencephaly-1 Subcortical Band Heterotopia Double Cortex Lissencephaly Classic Lissencephaly Sequence Isolated Isolated Lissencephaly Sequence Type 1 Lissencephaly Lissencephaly Syndrome Type 1 SBH Sclh Lissencephaly, Type 1 Type I Lissencephaly
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Fucosidosis	Alpha-L-Fucosidase Deficiency Fucosidase Deficiency Disease A-Fucosidase Deficiency Alpha Fucosidase Deficiency Lysosomal Storage Disease Caused By Defective Alpha-L-Fucosidase With Accumulation Of Fucose In The Tissues Alpha-Fucosidase Deficiency Fucosidase Deficiency FUCA1D
Cerebellar Hypoplasia
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Retinitis Pigmentosa 1	RP1 Retinitis Pigmentosa-1 Retinitis Pigmentosa, Type 1
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Lissencephaly 10	LIS10
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Ganglioglioma	Childhood Ganglioglioma Adult Ganglioglioma Cns Ganglioglioma Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Brain Oligodendroglioma	Oligodendroglioma Of Brain
Miller-Dieker Lissencephaly Syndrome	Miller-Dieker Syndrome Mds MDLS Miller Dieker Syndrome Classical Lissencephaly Syndrome Lissencephaly Due To 17p13.3 Deletion Monosomy 17p13.3 Telomeric Deletion 17p Classical Lissencephaly
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Lissencephaly 7 With Cerebellar Hypoplasia	LIS7 Lissencephaly 7, With Cerebellar Hypoplasia Lissencephaly, Type 7, With Cerebellar Hypoplasia
Polymicrogyria, Bilateral Perisylvian, X-Linked	Bilateral Perisylvian Polymicrogyria Polymicrogyria, Bilateral Perisylvian Pmgx Perisylvian Syndrome, Congenital Bilateral Cbps Congenital Bilateral Perisylvian Syndrome Perisylvian Syndrome BPPX Bpp
Chromosome 17p13.3, Centromeric, Duplication Syndrome	Chromosome 17p13.3 Duplication Syndrome 17p13.3 Duplication Syndrome 17p13.3 Microduplication Syndrome Trisomy 17p13.3 Chromosome 17p13.3 Centromeric Duplication Syndrome Dup(17)(P13.3)
Schizophrenia 12	Sczd12 Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117787	TUG-905	Agonist	/	Unkown
HY-RS03601	DCX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17791	Dcx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24259	Dcx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCX	MGD	MGI:1277171
Rattus norvegicus	DCX	RGD	RGD:620670
Bos taurus	DCX	VGNC	VGNC:56525
Canis familiaris	DCX	VGNC	VGNC:54132
Others	DCX	NCBI