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GOLM1 - golgi membrane protein 1 Gene

Also Known as GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51280

About GOLM1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:86,026,146-86,100,149 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues.

Summary

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral Infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]

GOLM1 Products (2)

mRNA	Protein	Name
NM_016548.4	NP_057632.2	Golgi membrane protein 1
NM_177937.3	NP_808800.1	Golgi membrane protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21280149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
Golgi membrane protein 1	epididymis luminal protein 46

GOLM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GOLM1	Q8NBJ4	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	SLC35B2	Homo sapiens	Q8TB61	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMUB1	Homo sapiens	Q9BVT8	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	SLC5A4	Homo sapiens	Q9NY91	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	SLCO3A1	Homo sapiens	Q9UIG8-2	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	GOLM1	Q8NBJ4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	GOLM1	Q8NBJ4	TMEM176A	Homo sapiens	Q96HP8	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	CNPY3	Homo sapiens	Q9BT09	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Anti Bait CoIP	27569582
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27569582
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Confocal	27569582
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Pull Down	27569582
Intra	GOLM1	Q8NBJ4	THSD7A	Homo sapiens	Q9UPZ6	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	FUT9	Homo sapiens	Q9Y231	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	NDUFV2	Homo sapiens	P19404	Y2H Prey Pooling	32296183
Intra	GOLM1	Q8NBJ4	NDUFV2	Homo sapiens	P19404	Y2H Array	32296183
Intra	GOLM1	Q8NBJ4	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM98	Homo sapiens	Q9Y2Y6	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	INSIG2	Homo sapiens	Q9Y5U4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GOLM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70879	GOLM1 Protein, Human (HEK293, His)	Q8NBJ4-1 (S36-L401)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72209	GOLM1 Protein, Human (His)	Q8NBJ4-1 (S36-L401)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72209A	GOLM1 Protein, Human (His, Solution)	Q8NBJ4-1 (S36-L401)	≥ 95%, as determined by reducing SDS-PAGE.

GOLM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83002	GOLPH2 Antibody (YA2747)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Wilson Disease	Hepatolenticular Degeneration WD Wilson'S Disease WND Westphal-Strumpell Syndrome Copper Storage Disease Cerebral Pseudosclerosis Westphal Pseudosclerosis Hepatolenticular Degeneration Syndrome Copper Retention Hepatocerebral Degeneration Kinnier-Wilson Disease Neurohepatic Degeneration Progressive Hepatolenticular Degeneration Lenticular Degenerative Disease Wilson'S Syndrome Lenticular Syndrome
Spinocerebellar Ataxia 44	SCA44

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05592	GOLM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19437	Golm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25928	Golm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990421	Anti-GOLM1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GOLM1	VGNC	VGNC:41345
Mus musculus	GOLM1	MGD	MGI:1917329
Rattus norvegicus	GOLM1	RGD	RGD:1589384
Macaca mulatta	GOLM1	VGNC	VGNC:72946
Felis catus	GOLM1	VGNC	VGNC:62643
Bos taurus	GOLM1	VGNC	VGNC:29491
Others	GOLM1	NCBI