2. Gene
  3. SLC35B2 - solute carrier family 35 member B2 Gene

SLC35B2 - solute carrier family 35 member B2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLL; PAPST1; UGTrel4

Gene ID: 347734 | Gene type: protein coding

About SLC35B2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,254,101-44,257,890 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 17.2), thyroid (RPKM 15.1) and 25 other tissues.

Summary

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

SLC35B2 Products(9)

mRNA Protein Name
NM_001286509.2 NP_001273438.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286510.2 NP_001273439.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286511.2 NP_001273440.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286512.2 NP_001273441.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286513.2 NP_001273442.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform d precursor
NM_001286517.2 NP_001273446.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e
NM_001286519.2 NP_001273448.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_001286520.2 NP_001273449.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_178148.4 NP_835361.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform a precursor

SLC35B2 Protein Structure

UAA

UAA: UAA transporter family (112 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

adenosine 3'-phospho 5'-phosphosulfate transporter 1

3'-phosphoadenosine 5'-phosphosulfate transporter

Related Diseases

Diseases Alias
Primary Bone Dysplasia With Multiple Joint Dislocations

Primary Osteodysplasia With Multiple Joint Dislocations

Primary Skeletal Dysplasia With Multiple Joint Dislocations
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13199 SLC35B2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC35B2 VGNC VGNC:46365
Rattus norvegicus SLC35B2 RGD RGD:1565318
Felis catus SLC35B2 VGNC VGNC:102518
Mus musculus SLC35B2 MGD MGI:1921086
Bos taurus SLC35B2 VGNC VGNC:34824
Macaca mulatta SLC35B2 VGNC VGNC:83469