country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

SLC35B2 - solute carrier family 35 member B2 Gene

Also Known as SLL; PAPST1; UGTrel4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 347734

About SLC35B2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,254,101-44,257,890 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 17.2), thyroid (RPKM 15.1) and 25 other tissues.

Summary

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

SLC35B2 Products (9)

mRNA	Protein	Name
NM_001286509.2	NP_001273438.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286510.2	NP_001273439.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286511.2	NP_001273440.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286512.2	NP_001273441.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286513.2	NP_001273442.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform d precursor
NM_001286517.2	NP_001273446.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e
NM_001286519.2	NP_001273448.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_001286520.2	NP_001273449.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_178148.4	NP_835361.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	12716889	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate transport	IDA IDA: Inferred from direct assay	12716889	GOA
involved in chondroitin sulfate biosynthetic process	IMP IMP: Inferred from mutant phenotype	35325049	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12716889	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	12716889	GOA
located in membrane	IDA IDA: Inferred from direct assay	12716889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35B2 Protein Structure

UAA

0
100
200
300
400
432 a.a.

Protein Preferred Names	Protein Names
adenosine 3'-phospho 5'-phosphosulfate transporter 1	3'-phosphoadenosine 5'-phosphosulfate transporter

SLC35B2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC35B2	Q8TB61	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	SLC35B2	Q8TB61	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	SLC35B2	Q8TB61	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	RNF170	Homo sapiens	Q96K19-5	Validated Y2H	32296183
Intra	SLC35B2	Q8TB61	RNF170	Homo sapiens	Q96K19-5	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	RNF170	Homo sapiens	Q96K19-5	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	CLDN15	Homo sapiens	Q96FX9	Validated Y2H	32296183
Intra	SLC35B2	Q8TB61	CLDN15	Homo sapiens	Q96FX9	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	CLDN15	Homo sapiens	Q96FX9	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	CD69	Homo sapiens	Q07108	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	CD69	Homo sapiens	Q07108	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SLC35B2	Q8TB61	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	SLC35B2	Q8TB61	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SLC35B2	Q8TB61	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SLC35B2	Q8TB61	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Primary Bone Dysplasia With Multiple Joint Dislocations	Primary Osteodysplasia With Multiple Joint Dislocations Primary Skeletal Dysplasia With Multiple Joint Dislocations

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13199	SLC35B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22040	Slc35b2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28557	Slc35b2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC35B2	VGNC	VGNC:46365
Rattus norvegicus	SLC35B2	RGD	RGD:1565318
Felis catus	SLC35B2	VGNC	VGNC:102518
Mus musculus	SLC35B2	MGD	MGI:1921086
Bos taurus	SLC35B2	VGNC	VGNC:34824
Macaca mulatta	SLC35B2	VGNC	VGNC:83469