PAPOLG - poly(A) polymerase gamma Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64895

About PAPOLG

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:60,756,268-60,802,086 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 5.8), testis (RPKM 3.7) and 25 other tissues.

Summary

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two Enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]

PAPOLG Products (1)

mRNA Protein Name
NM_022894.4 NP_075045.2 poly(A) polymerase gamma

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metal ion binding IDA
IDA: Inferred from direct assay
24076191 GOA
enables poly(A) RNA polymerase activity IDA
IDA: Inferred from direct assay
11463842 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11463842 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAPOLG Protein Structure

PAP_central

PAP_central: Poly(A) polymerase central domain (16 - 363)

NTP_transf_2

NTP_transf_2: Nucleotidyltransferase domain (94 - 172)

PAP_RNA-bind

PAP_RNA-bind: Poly(A) polymerase predicted RNA binding domain (365 - 506)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
Protein Preferred Names Protein Names

poly(A) polymerase gamma

  • PAP-gamma

Related Diseases

Diseases Alias
Acute Cystitis

  • Urinary Tract Infection

  • Recurrent Urinary Tract Infection
Pyelitis
Chromosome 2p16.1-P15 Deletion Syndrome

  • 2p15p16.1 Microdeletion Syndrome

  • 2p15-P16.1 Microdeletion Syndrome

  • Del(2)(P15p16.1)

  • Monosomy 2p15p16.1

  • Monosomy 2p15-P16.1
Peroxisome Biogenesis Disorder 11a

  • PBD11A

  • Peroxisome Biogenesis Disorder Complementation Group 13

  • PBD-CG13

  • Cg13

  • Pbd-Cgh

  • Peroxisome Biogenesis Disorder Complementation Group H

  • Peroxisome Biogenesis Disorder, Type 11a

  • Peroxisome Biogenesis Disorder, Complementation Group 13
Acute Pyelonephritis

  • Apn - [Acute Pyelonephritis]
Bacteriuria
Urinary Tract Infection

  • Urinary Tract Infections

  • Uti

  • Urinary Tract Infection Nos

  • Uti - [Urinary Tract Infection]

  • Uti Nos - [Urinary Tract Infection Nos]

  • Urosepsis Nos

  • E Coli Uti

  • E Coli Urinary Tract Infection

  • Escherichia Coli Uti
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10027 PAPOLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PAPOLG MGD MGI:2442119
Rattus norvegicus PAPOLG RGD RGD:1310337
Canis familiaris PAPOLG VGNC VGNC:54531
Felis catus PAPOLG VGNC VGNC:81139
Macaca mulatta PAPOLG VGNC VGNC:106193
Others PAPOLG NCBI