ARPC1A - actin related protein 2/3 complex subunit 1A Gene
Also Known as Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307
Species: Homo sapiens
About ARPC1A
This gene has 5 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 48.9), stomach (RPKM 46.5) and 25 other tissues.
Summary
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
ARPC1A Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001190996.2 | NP_001177925.1 | actin-related protein 2月3日 complex subunit 1A isoform 2 |
| NM_006409.4 | NP_006400.2 | actin-related protein 2月3日 complex subunit 1A isoform 1 |
ARPC1A Protein Structure
WD40: WD domain, G-beta repeat (45 - 80)
WD40: WD domain, G-beta repeat (135 - 170)
- 0
- 100
- 200
- 300
- 370 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
actin-related protein 2/3 complex subunit 1A |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Fanconi Anemia, Complementation Group G |
|
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| Scapuloperoneal Myopathy |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | ARPC1A | VGNC | VGNC:50215 |
| Mus musculus | ARPC1A | MGD | MGI:1928896 |
| Canis familiaris | ARPC1A | VGNC | VGNC:49924 |
| Rattus norvegicus | ARPC1A | RGD | RGD:620834 |
| Felis catus | ARPC1A | VGNC | VGNC:80551 |
| Others | ARPC1A | NCBI |