Gabrb3 - gamma-aminobutyric acid type A receptor subunit beta 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24922

Summary

Enables AP-2 adaptor complex binding activity; GABA-A receptor activity; and Chloride Channel activity. Involved in GABAergic synaptic transmission. Located in inhibitory synapse; plasma membrane; and terminal bouton. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in childhood absence epilepsy and developmental and epileptic encephalopathy 43. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb3 Products (1)

mRNA Protein Name
NM_017065.2 NP_058761.2 gamma-aminobutyric acid receptor subunit beta-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AP-2 adaptor complex binding IPI
IPI: Inferred from physical interaction
16192353 RGD
enables GABA-A receptor activity IDA
IDA: Inferred from direct assay
2548852 RGD
enables GABA-gated chloride ion channel activity IDA
IDA: Inferred from direct assay
10462548 RGD
enables chloride channel activity IDA
IDA: Inferred from direct assay
12356876 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12812758 RGD
Biological Process GO Annotation Evidence References Source
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
19774669 RGD
involved in synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
12356876 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
21073549 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
15474980 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
20417281 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9464994 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
21073549 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
21073549 RGD
located in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9464994 RGD
located in sperm head IDA
IDA: Inferred from direct assay
15474980 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
12812758 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit beta-3

  • GABA(A) receptor subunit beta-3

  • GABA-alpha receptor beta-3 subunit

  • Gamma-aminobutyric acid receptor beta 3

  • gamma-aminobutyric acid (GABA) A receptor, beta 3

  • gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3

  • gamma-aminobutyric acid type A rece

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05217 GABRB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrb3 NCBI NCBI:2562