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DS18561882 

Cat. No.: HY-130251
Handling Instructions

DS18561882 is a highly potent, sozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor a good oral pharmacokinetic profile. DS18561882 shows a cell-based activity with a GI value of 140 nM.

For research use only. We do not sell to patients.

DS18561882 Chemical Structure

DS18561882 Chemical Structure

CAS No. : 2227149-22-4

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Description

DS18561882 is a highly potent, sozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor a good oral pharmacokinetic profile. DS18561882 shows a cell-based activity with a GI value of 140 nM[1].

IC50 & Target

GI50: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)[1]

In Vitro

DS18561882 (0-150 nM) gives the lowest GI50 value (140 nM) against the MDA-MB-231 cell line[1].

In Vivo

DS18561882 (oral administration; 30-300mg/kg; twice daily) inhibits tumor growth inhibition with a dose-dependent manner, the tumor is completely inhibited (TGI: 67%) at the dose of 300 mg/kg in mice[1].
DS18561882 (oral administration; 30-300mg/kg; twice daily) has a good oral pharmacokinetic profile, including ACU (64.6, 264, 726 μg.h/ml ); Cmax (11.4, 56.5, 90.1 μg/ml); t1/2 (2.21, 2.16, 2.32 hours) for 30 mg/kg; 100mg/kg; 200 mg/kg, respectively[1].

Animal Model: Male balb/c mice[1]
Dosage: 30 mg/kg; 100 mg/kg; 200 mg/kg; 300 mg/kg
Administration: Oral administration; 30-300 mg/kg; twice daily
Result: Suppressed tumor growth in a dose-dependent manner.
Molecular Weight

608.63

Formula

C₂₈H₃₁F₃N₄O₆S

CAS No.

2227149-22-4

SMILES

CS(=O)(NC1=CC=C(C(N2CCC(C3=CC=C(N4C[[email protected]](C)N(C)CC4)C(C)=C3O5)=C(C5=O)C2)=O)C=C1OC(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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DS18561882
Cat. No.:
HY-130251
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