2227149-22-4
Chemical Structure
DS18561882
- CAS No.: 2227149-22-4
- Formula:C28H31F3N4O6S
- Molecular Weight:608.63
IUPAC Name: (S)-N-(4-(8-(3,4-dimethylpiperazin-1-yl)-7-methyl-5-oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)-2-(trifluoromethoxy)phenyl)methanesulfonamide
InChIKey: OQKAKSSZSQPTDZ-INIZCTEOSA-N
SMILES: CS(=O)(NC1=CC=C(C(N2CCC(C3=CC=C(N4C[C@H](C)N(C)CC4)C(C)=C3O5)=C(C5=O)C2)=O)C=C1OC(F)(F)F)=O
Biological Activity: DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DS18561882 | 99.95% | DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 (IC50=0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile. | ||||||||||||||||||||
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Keywords
