1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. BAY885

BAY885 

Cat. No.: HY-112082 Purity: 99.15%
Handling Instructions

BAY885 is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases.

For research use only. We do not sell to patients.

BAY885 Chemical Structure

BAY885 Chemical Structure

CAS No. : 2307249-33-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 510 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BAY885 is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases[1].

IC50 & Target[1]

ERK5

35 nM (IC50)

In Vitro

The ERK5 probe 41 (BAY-885) showed potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and had no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

515.53

Formula

C₂₅H₂₈F₃N₇O₂

CAS No.

2307249-33-6

SMILES

O=C(C1=CC=C(OC(F)(F)F)C=C1N)N(CC2)CCC2C3=NC=NC4=CC(N5CCN(C)CC5)=CN=C43

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (32.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9398 mL 9.6988 mL 19.3975 mL
5 mM 0.3880 mL 1.9398 mL 3.8795 mL
10 mM 0.1940 mL 0.9699 mL 1.9398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (3.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (3.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.15%

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Keywords:

BAY885BAY 885BAY-885ERKExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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BAY885
Cat. No.:
HY-112082
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