2. Protein Tyrosine Kinase/RTK
  3. RET
  4. BT44

BT44 is a selective RET activator. BT44 can penetrate through the blood-brain barrier and can be used for the research of neurodegenerative disorders and diabetes mellitus.

For research use only. We do not sell to patients.

BT44 Chemical Structure

BT44 Chemical Structure

CAS No. : 924759-42-2

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Based on 1 publication(s) in Google Scholar

BT44 Related Antibodies

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Description

BT44 is a selective RET activator. BT44 can penetrate through the blood-brain barrier and can be used for the research of neurodegenerative disorders and diabetes mellitus[1][2].

In Vitro

BT44 (7.5-75 μM; 15 min) promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors[1].
BT44 (0.5-10 μM; 16-20 h) promotes neurite outgrowth from sensory neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BT44 Related Antibodies

Western Blot Analysis[1]

Cell Line: GFRα3-transfected MG87RET cells
Concentration: 7.5, 18, 35 and 75 μM
Incubation Time: 15 min
Result: Increased RET and ERK phosphorylation.
In Vivo

BT44 (5-25 mg/kg; s.c.; every second day for 10, 42 or 14 days) alleviates sensory signs in the SNL and STZ models of neuropathic[1].
BT44 (12.5 or 25 mg/kg; s.c.; every second day for 10 days) protects IB4-positive neurons in DRGs of animals with experimental neuropathy[1].
BT44 (0.1 and 0.3 μg/24 h; infuse into the right dorsal striatum for 14 days) reverses amphetamine-induced motor imbalance and seems to protect dopaminergic fibers in the striatum in 6-OHDA rat model of Parkinson’s disease[2].
BT44 (10 mg/kg; i.v.) penetrates the blood-brain barrier and is rapidly eliminated from the circulation (half-life (t1/2) = 0.72 h) and brain (t1/2 = 0.47 h) in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats, spinal nerve ligation (SNL) and Streptozotocin (STZ; HY-13753)-induced diabetes mellitus models[1]
Dosage: 5, 12.5 or 25 mg/kg
Administration: Subcutaneous injecton, every second day for 10, 42 or 14 days
Result: Alleviated mechanical allodynia in the SNL animals. Treatment with the dose of 5 mg/kg alleviated mechanical hyperalgesia in the STZ-treated animals, while the 12.5 mg/kg dose was not effective. Concentration of 5 mg/kg attenuated cold allodynia in the STZ-treated animals during the first two weeks while the effect of 12.5 mg/kg was not significant.
Animal Model: Wistar rats, SNL-induced diabetes mellitus model[1]
Dosage: 12.5 or 25 mg/kg
Administration: Subcutaneous injecton, every second day for 10 days
Result: Led to a significant increase in the number of IB4 expressing neurons in the ipsilateral DRGs. The 12.5 mg/kg dose protected IB4-positive neurons from SNL-induced lesion.
Molecular Weight

577.59

Formula

C28H27F4N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C2=CC(S(=O)(N3CC4=C(CC3)C=CC=C4)=O)=CC=C2OC)C5=CC=C(C=C5C(F)(F)F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (108.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7313 mL 8.6567 mL 17.3133 mL
5 mM 0.3463 mL 1.7313 mL 3.4627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7313 mL 8.6567 mL 17.3133 mL 43.2833 mL
5 mM 0.3463 mL 1.7313 mL 3.4627 mL 8.6567 mL
10 mM 0.1731 mL 0.8657 mL 1.7313 mL 4.3283 mL
15 mM 0.1154 mL 0.5771 mL 1.1542 mL 2.8856 mL
20 mM 0.0866 mL 0.4328 mL 0.8657 mL 2.1642 mL
25 mM 0.0693 mL 0.3463 mL 0.6925 mL 1.7313 mL
30 mM 0.0577 mL 0.2886 mL 0.5771 mL 1.4428 mL
40 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0821 mL
50 mM 0.0346 mL 0.1731 mL 0.3463 mL 0.8657 mL
60 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.7214 mL
80 mM 0.0216 mL 0.1082 mL 0.2164 mL 0.5410 mL
100 mM 0.0173 mL 0.0866 mL 0.1731 mL 0.4328 mL
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BT44 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BT44924759-42-2BT 44BT-44RETParkinson’s diseaseSTZdiabetes mellitusGFRα3blood-brain barrierInhibitorinhibitorinhibit

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