DHX34 - DExH-box helicase 34 Gene

Also Known as HRH1; DDX34

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9704

About DHX34

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,349,315-47,382,704 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 9.0), bone marrow (RPKM 4.3) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

DHX34 Products (1)

mRNA Protein Name
NM_014681.6 NP_055496.2 probable ATP-dependent RNA helicase DHX34

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables ATP hydrolysis activity IMP
IMP: Inferred from mutant phenotype
33205750 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25220460 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
26841701 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
IMP: Inferred from mutant phenotype
23828042 GOA
involved in nuclear-transcribed mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
23828042 GOA
involved in positive regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
26841701 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX34 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (173 - 315)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (410 - 496)

HA2

HA2: Helicase associated domain (HA2) (557 - 645)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (686 - 910)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1143 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DHX34

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34

Related Diseases

Diseases Alias
Pulmonary Emphysema
Renal Hypodysplasia/Aplasia 3

  • RHDA3

  • Renal Agenesis, Unilateral

  • Unilateral Renal Agenesis
Polydactyly, Postaxial, Type A1

  • Postaxial Polydactyly Type A

  • Polydactyly, Postaxial

  • Postaxial Polydactyly

  • PAPA1

  • Postaxial Polydactyly, Type A

  • Papa

  • Polydactyly, Postaxial, Types A1 And B

  • Postaxial Polydactyly Type B

  • Polydactyly Postaxial

  • Polydactyly, Postaxial A1

  • Polydactyly, Postaxial B

  • PAPB

  • Postaxial Polydactyly, Type A1/B

  • Polydactyly, Postaxial, Type A

  • Pyogenic Arthritis, Pyoderma Gangrenosum And Acne

  • Postaxial Polydactyly, Type B
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Immunodeficiency 51

  • IMD51

  • Candf5

  • Candidiasis, Familial, 5

  • Candidiasis, Familial, 5, Formerly

  • Candf5, Formerly

  • Familial Candidiasis 5

  • Candidiasis Familial 5 Autosomal Recessive

  • Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

  • Chronic Mucocutaneous Candidiasis 5
Pelger-Huet Anomaly

  • PHA

  • Pelger-Huët Anomaly

  • Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

  • Pelger Huet Anomaly

  • Pelger-Huet Nuclear Anomaly
Pancreatic Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Pancreas

  • Adenosquamous Carcinoma Of The Pancreas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS03753 DHX34 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DHX34 VGNC VGNC:71634
Felis catus DHX34 VGNC VGNC:61479
Mus musculus DHX34 MGD MGI:1918973
Rattus norvegicus DHX34 RGD RGD:1584452
Canis familiaris DHX34 VGNC VGNC:39944
Bos taurus DHX34 VGNC VGNC:28052
Others DHX34 NCBI