1. Cell Cycle/DNA Damage
  2. PPAR
  3. FK614

FK614 

Cat. No.: HY-101292 Purity: 99.50%
Handling Instructions

FK614 is an orally active, potent, selective PPARγ modulator (SPPARM). FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 is a nonthiazolidinedione insulin sensitizer. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes.

For research use only. We do not sell to patients.

FK614 Chemical Structure

FK614 Chemical Structure

CAS No. : 193012-35-0

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5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
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50 mg USD 3500 Get quote
100 mg USD 4800 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

FK614 is an orally active, potent, selective PPARγ modulator (SPPARM). FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 is a nonthiazolidinedione insulin sensitizer. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes[1][2][3].

IC50 & Target

PPAR-γ

 

In Vitro

FK614 (0.1~10000 nM; 24 hours; CV-1 cells) activates PPARγ-dependent transcription in a concentration-dependent manner. FK614 (0~0.1 μM; 5 days; 3T3-L1 adipocytes) makes triglyceride content increased in a concentration-dependent manner. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 is an insulin sensitizer potentially for treatment of postherpetic neuralgia[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FK614 (0.32~3.2 mg/kg; p.o.; 14 days) dose-dependently reduces plasma glucose level[3].
FK614 (0.1~10 mg/kg; p.o.; 14 days) improves the impaired glucose tolerance[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db Mice
Dosage: 0.1~10 mg/kg
Administration: P.o.
Result: Improved the impaired glucose tolerance.
Animal Model: db/db Mice
Dosage: 0.32~3.2 mg/kg
Administration: P.o.
Result: Dose-dependently reduced plasma glucose level.
Molecular Weight

468.40

Formula

C₂₁H₂₃Cl₂N₃O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Product Name:
FK614
Cat. No.:
HY-101292
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