193012-35-0
Chemical Structure
FK614
- CAS No.: 193012-35-0
- Formula:C21H23Cl2N3O3S
- Molecular Weight:468.40
IUPAC Name: 1-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-1H-benzo[d]imidazole-6-carboxamide
InChIKey: UYGZODVVDUIDDQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(C)N(CC3=CC=C(Cl)C=C3Cl)C2=C1)NS(=O)(CCCCC)=O
Biological Activity: FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 functions as a PPARγ agonist with potent anti-diabetic activity in vivo. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FK614 | 99.97% | FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 functions as a PPARγ agonist with potent anti-diabetic activity in vivo. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes. | ||||||||||||||||||||
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FK614 (Standard) | ≥98% | FK614 (Standard) is the analytical standard of FK614 (HY-101292). This product is intended for research and analytical applications. FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 functions as a PPARγ agonist with potent anti-diabetic activity in vivo. FK614 has different effects on the activation of PPARγ at each stage of adipocyte differentiation. FK614 can be used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes. | ||||||||||||||||||||
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Similarity Score 0.85
HY-105686RFR-229934 (Standard) -
Similarity Score 0.49
HY-118249GSK 1997132B -
Similarity Score 0.49
HY-124814C215 -
Similarity Score 0.48
![1-Benzyl-4-hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide Chemical Structure](//file.medchemexpress.com/product_pic/hy-47848.gif)
HY-478481-Benzyl-4-hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide -
Similarity Score 0.48
HY-117390FR-181074 -
Similarity Score 0.48
HY-B1144AChlormidazole hydrochloride -
Similarity Score 0.48
HY-18996RAdjudin (Standard) -
Similarity Score 0.48
HY-120327KY-226 -
Similarity Score 0.47
HY-105198Lexipafant -
Explore the MedChemAI to find more analogs
![1-Benzyl-4-hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide Chemical Structure](http://file.medchemexpress.com/product_pic/hy-47848.gif)
References
- [1]. Fujimura T, et al. A selective peroxisome proliferator-activated receptor gamma modulator with distinct fat cell regulation properties. J Pharmacol Exp Ther. 2006;318(2):863-871. [Content Brief]
- [2]. Fujimura T, et al. FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators. J Pharmacol Sci. 2005;99(4):342-352. [Content Brief]
