CK2-IN-9
CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC50 of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC50 of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.
For research use only. We do not sell to patients.
- CAS No.: 1461658-58-1
- Formula: C23H29N9O
- Molecular Weight:447.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
4 μM
Compound: 7b
|
Inhibition of human ERG expressed in CHO cells by patch clamp assay
Inhibition of human ERG expressed in CHO cells by patch clamp assay
|
[PMID: 26985319] |
| DLD-1 | GI50 |
0.08 μM
Compound: 7b
|
Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay
Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay
|
[PMID: 26985319] |
| HCT-116 | GI50 |
0.03 μM
Compound: 7b
|
Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay
Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay
|
[PMID: 26985319] |
| HCT-116 | GI50 |
0.03 μM
Compound: Example 1
|
Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay
|
[PMID: 24900617] |
| Sf21 | IC50 |
<0.003 μM
Compound: 7b
|
Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay
Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay
|
[PMID: 26985319] |
| SW-620 | GI50 |
0.03 μM
Compound: 7b
|
Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay
Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay
|
[PMID: 26985319] |
Chemical Information
-
CAS No. 1461658-58-1
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Molecular Weight 447.54
-
Formula C23H29N9O
-
SMILES
O=C(C)NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N(CCN(C)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)