Antileishmanial agent-22
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM.
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- Fòrmula: C29H26Cl2N4O3
- Peso molecular:549.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 0.408 μM (leishmanial), 0.038 μM (P. berghei); MIC: 28.44 μM (M. tuberculosis)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
455 μM
Compound: 15b
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Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
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[PMID: 37269671] |
Chemical Information
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Peso molecular 549.45
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Fòrmula C29H26Cl2N4O3
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SMILES
O=C(C1CCN(C(C)=O)CC1)NCC2=CC=C3CCC4=C(NC(C(C#N)=C4C5=C(Cl)C=CC(Cl)=C5)=O)C3=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-22 Related Classifications
HY-155846 Related Classifications
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