Carmaphycin-17
Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC50 of 217 ?nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research.
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- No. CAS: 2143080-91-3
- Fòrmula: C40H45N5O5
- Peso molecular:675.82
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
346 nM
Compound: 17
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Cytotoxicity against human HepG2 cells harboring A16-CD81EGFP assessed as cell viability after 48 hrs by bioluminescence assay
Cytotoxicity against human HepG2 cells harboring A16-CD81EGFP assessed as cell viability after 48 hrs by bioluminescence assay
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[PMID: 28696697] |
Chemical Information
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No. CAS 2143080-91-3
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Peso molecular 675.82
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Fòrmula C40H45N5O5
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SMILES
O=C([C@]1(CO1)C)[C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CCCCC)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CNC6=CC=CC=C56)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carmaphycin-17 Related Classifications
HY-171956 Related Classifications
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