5-LOX/sEH-IN-1
5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.
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- No. CAS: 3040383-48-7
- Fòrmula: C18H15N7O
- Peso molecular:345.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Referencias
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Help & FAQs
Actividad biológica
IC50: 10.5 μM (COX-2)[1].
IC50: 2.20 nM (sEH)[1].
IC50: 3.05 μM (5-LOX)[1].
Chemical Information
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No. CAS 3040383-48-7
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Peso molecular 345.36
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Fòrmula C18H15N7O
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SMILES
N#CC1=C(N)N2C(NC1C3=CC=C(OC)C=C3)=NN=C2C4=CC=CN=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-LOX/sEH-IN-1 Related Classifications
HY-159169 Related Classifications
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