DTX-P7
DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90.
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- Fòrmula: C84H118N8O25
- Peso molecular:1639.87
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
11.4 nM
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PMID: 35659720 |
| C3H/3T3 | IC50 |
11.4 nM
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PMID: 35659720 |
| H1975 | IC50 |
0.62 nM
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PMID: 35659720 |
| M21 | IC50 |
0.62 nM
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PMID: 35659720 |
DTX-P7 inhibits the expression of membrane Hsp90 in dose- and time-dependent manners, while no change in mRNA level is observed[1].
DTX-P7 enhances phosphorylation of PERK and eIF2α, whereas no XBP-1 RNA splicing is observed when A549 cells are exposed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 1639.87
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Fòrmula C84H118N8O25
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DTX-P7 Related Classifications
HY-P10757 Related Classifications
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