Ethyl oleate
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Ethyl oleate is an orally active fatty acid ester formed from the condensation of oleic acid and ethanol. Ethyl oleate is the main fatty acid ethyl ester in the blood after alcohol ingestion. Ethyl oleate has no obvious toxicity to rats and its absorption, distribution and excretionare similar to triacylglycerol. Ethyl oleate can accelerate the drying process of certain foods and can also be used as a liquid lipid component in nanostructured lipid carriers.
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- Pureza: 98.0%
- No. CAS: 111-62-6
- Fòrmula: C20H38O2
- Peso molecular:310.51
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Fatty acid ethyl esters (FAEEs) can be synthesized by adding ethanol in Hep G2 cells, in which Ethyl palmitate (HY-N2086) and Ethyl oleate are the main FAEEs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 111-62-6
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Appearance Liquid (Density: 0.8842 g/cm3)
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Peso molecular 310.51
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Fòrmula C20H38O2
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Color Colorless to light yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(OCC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (161.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (8.05 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (396 KB)
- English - EN (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Dan L, et al. Ethyl palmitate and ethyl oleate are the predominant fatty acid ethyl esters in the blood after ethanol ingestion and their synthesis is differentially influenced by the extracellular concentrations of their corresponding fatty acids. Alcohol Clin Exp Res. 1997 Apr;21(2):286-92. [Content Brief]
[2]. Bookstaff RC, et al. The safety of the use of ethyl oleate in food is supported by metabolism data in rats and clinical safety data in humans. Regul Toxicol Pharmacol. 2003 Feb;37(1):133-48. [Content Brief]
[3]. Zhang Y, et al. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid ascompared with conventional solid lipid nanoparticles. Int J Pharm. 2016 Sep 10;511(1):57-64. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2205 mL | 16.1025 mL | 32.2051 mL | 80.5127 mL |
| 5 mM | 0.6441 mL | 3.2205 mL | 6.4410 mL | 16.1025 mL | |
| 10 mM | 0.3221 mL | 1.6103 mL | 3.2205 mL | 8.0513 mL | |
| 15 mM | 0.2147 mL | 1.0735 mL | 2.1470 mL | 5.3675 mL | |
| 20 mM | 0.1610 mL | 0.8051 mL | 1.6103 mL | 4.0256 mL | |
| 25 mM | 0.1288 mL | 0.6441 mL | 1.2882 mL | 3.2205 mL | |
| 30 mM | 0.1074 mL | 0.5368 mL | 1.0735 mL | 2.6838 mL | |
| 40 mM | 0.0805 mL | 0.4026 mL | 0.8051 mL | 2.0128 mL | |
| 50 mM | 0.0644 mL | 0.3221 mL | 0.6441 mL | 1.6103 mL | |
| 60 mM | 0.0537 mL | 0.2684 mL | 0.5368 mL | 1.3419 mL | |
| 80 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 1.0064 mL | |
| 100 mM | 0.0322 mL | 0.1610 mL | 0.3221 mL | 0.8051 mL |
Ethyl oleate Related Classifications
HY-N7103 Related Classifications
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