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Referencia número: HY-174393

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Gamhepathiopine

Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Q_o site of Plasmodium falciparum cytochrome b and inhibiting the activity of complex III in the electron transport chain.

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No. CAS: 1620442-30-9
Fòrmula: C₁₇H₁₉N₃OS
Peso molecular:313.42

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Gamhepathiopine Chemical Structure

No. CAS: 1620442-30-9

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Chemical Information
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Descripciòn

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	CC₅₀	27.5 μM Compound: 1	Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 25791675]
Hepatocyte	CC₅₀	>200 μM Compound: 1	Cytotoxicity against cynomolgus monkey Primary hepatocyte assessed as cell viability Cytotoxicity against cynomolgus monkey Primary hepatocyte assessed as cell viability	[PMID: 36680984]
HepG2	CC₅₀	25.6 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 25791675]

Chemical Information

No. CAS 1620442-30-9
Peso molecular 313.42
Fòrmula C₁₇H₁₉N₃OS
SMILES

CC1=CC=C(C2=CC(N=C(NC(C)(C)C)NC3=O)=C3S2)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wiedemar N, et al. The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b. ACS Infect Dis. 2025 Jun 13;11(6):1719-1728. [Content Brief]

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Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Gamhepathiopine

Ver todos los productos específicos de isoformas Parasite

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Gamhepathiopine Related Classifications

HY-174393 Related Classifications