Genz-669178
Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice.
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- No. CAS: 1254834-91-7
- Fòrmula: C17H14N4OS
- Peso molecular:322.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | IC50 |
53 μM
Compound: 2q
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Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assay
Inhibition of human ERG expressed in CHOK1 cells by whole cell voltage clamp assay
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[PMID: 24900364] |
Chemical Information
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No. CAS 1254834-91-7
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Peso molecular 322.38
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Fòrmula C17H14N4OS
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SMILES
O=C(NC1CC1)C2=CC=C(S2)N3C4=CC=CC(C#N)=C4N=C3C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Genz-669178 Related Classifications
HY-120462 Related Classifications
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