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Referencia número: HY-123819

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KRH-1636

KRH-1636 is a CXC chemokine receptor (CXCR) 4 antagonist. KRH-1636 can be used in HIV-1 research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 568526-77-2
Fòrmula: C₃₂H₃₇N₇O₂
Peso molecular:551.68

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

KRH-1636 Chemical Structure

No. CAS: 568526-77-2

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
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Bioz

Actividad biológica

Descripciòn

KRH-1636 is a CXC chemokine receptor (CXCR) 4 antagonist. KRH-1636 can be used in HIV-1 research^[1].

IC₅₀ & Target

CXCR4

Ver todos los productos específicos de isoformas CXCR :

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	400 μM Compound: KRH-1636	Cytotoxicity against human MT4 cells assessed as reduction in cell viability Cytotoxicity against human MT4 cells assessed as reduction in cell viability	[PMID: 29500940]
MT4	CC₅₀	80 μM Compound: KRH-1636	Cytotoxicity against human MT4 cells assessed as reduction of cell viability Cytotoxicity against human MT4 cells assessed as reduction of cell viability	[PMID: 22579418]
MT4	EC₅₀	0.33 μM Compound: KRH-1636	Antiviral activity against X4-tropic HIV1 NL4.3 infected in human MT4 cells assessed as protection from virus-induced cytopathogenicity Antiviral activity against X4-tropic HIV1 NL4.3 infected in human MT4 cells assessed as protection from virus-induced cytopathogenicity	[PMID: 22579418]

Chemical Information

No. CAS 568526-77-2
Peso molecular 551.68
Fòrmula C₃₂H₃₇N₇O₂
SMILES

O=C(N[C@H](C(N[C@H](C1=C2C=CC=CC2=CC=C1)C)=O)CCCNC(N)=N)C3=CC=C(CNCC4=NC=CC=C4)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Ichiyama K, et al. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4185-90. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Pureza y Documentación
Referencias

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KRH-1636

Ver todos los productos específicos de isoformas CXCR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

KRH-1636 Related Classifications

HY-123819 Related Classifications