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Referencia número: HY-118726

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Luotonin F

Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II.

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No. CAS: 244616-85-1
Fòrmula: C₁₈H₁₁N₃O₂
Peso molecular:301.30

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Luotonin F Chemical Structure

No. CAS: 244616-85-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II^[1]^[2].

IC₅₀ & Target^[2]

Topoisomerase II

Ver todos los productos específicos de isoformas Topoisomerase :

Cellular Effect

Cell Line	Type	Value	Description	References
P388	IC₅₀	20 μg/mL Compound: 4	Cytotoxic activity against mouse leukemia P-388 cells Cytotoxic activity against mouse leukemia P-388 cells	[PMID: 14980663]

In Vitro

Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells (IC₅₀: 2.3 μg/mL)^[1].
Luotonin F (25 μM) inhibits human topoisomerase II^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 244616-85-1
Peso molecular 301.30
Fòrmula C₁₈H₁₁N₃O₂
SMILES

O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16(6):4861-83. [Content Brief]

[2]. Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
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Luotonin F

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Topoisomerase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Luotonin F Related Classifications

HY-118726 Related Classifications