p-F-HHSiD
p-F-HHSiD (p-Fluorohexahydrosiladifenidol) is a potent and selective M3 mAChR antagonist. p-F-HHSiD has antagonistic effects on other subtypes of the M receptor and the alpha1-adrenoceptor. p-F-HHSiD can be used for the researches of cancer, metabolic, neurological and cardiovascular disease such as, colon cancer, Alzheimer’s disease and diabetes.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 116679-83-5
- Fòrmula: C20H32FNOSi
- Peso molecular:349.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
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mAChR1 |
mAChR2 |
mAChR3 |
mAChR4 |
mAChR5 |
α1-adrenergic receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Astrocyte | EC50 |
5.815 μM
Compound: 8, p-F-HHSiD
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Antiproliferative activity against mouse astrocyte cells by MTT assay
Antiproliferative activity against mouse astrocyte cells by MTT assay
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[PMID: 17417631] |
| Medulloblastoma cell | EC50 |
1.125 μM
Compound: 8, p-F-HHSiD
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Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay
Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay
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[PMID: 17417631] |
Chemical Information
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No. CAS 116679-83-5
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Peso molecular 349.56
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Fòrmula C20H32FNOSi
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SMILES
FC1=CC=C([Si](CCCN2CCCCC2)(C3CCCCC3)O)C=C1
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Synonyms
p-Fluorohexahydrosiladifenidol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Eglen RM, et al. Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. [Content Brief]
[2]. Cheng K, et al. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G591-7. [Content Brief]
[3]. Nishimaru K, et al. Positive and negative inotropic effects of muscarinic receptor stimulation in mouse left atria. Life Sci. 2000;66(7):607-15. [Content Brief]
[4]. Svensson AL, et al. Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists. Brain Res. 1992 Nov 20;596(1-2):142-8. [Content Brief]
[5]. He Y, et al. GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep. 2025 Jul 7;15(1):24308. [Content Brief]
[6]. Shinoura H, et al. Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2002 Oct;366(4):368-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p-F-HHSiD Related Classifications
HY-137388 Related Classifications
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