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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
exploratory
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "exploratory" in MCE Product Catalog:
14
14 Publications Verification
1
1 Cited Publications
Referencia número: HY-P0267
No. CAS: 121062-08-6
Target:
Áreas de investigación:
1
Category:
Alkaloids Neurological Disease Leguminosae Other Alkaloids Plants Crotalaria pallida Ait. Disease Research Fields Endocrinology
Target:
1
Target:
Áreas de investigación:
Mianserin (Mianserine) is an orally active H1 receptor antagonist. Mianserin can activate κ-opioid receptor and octopamine receptor. Mianserin increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A (HY-P1333)-induced MAPK phosphorylation. Mianserin modulates social and exploratory behaviour, raises electroconvulsive thresholds. Mianserin can be used for the research of neurological disease, such as depression and epilepsy .
Referencia número: HY-172550
No. CAS: 3095336-10-7
Target:
Áreas de investigación:
MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated Ih current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder .
Referencia número: HY-17549
No. CAS: 63547-13-7
Synonyms: CRL 40028
Target:
Áreas de investigación:
Adrafinil (CRL 40028) is an orally active vigilance promoting agent. Adrafinil enhances central noradrenergic transmission, improves spontaneous activity, exploratory behavior, discriminative learning ability and response motivation, but impairs visuospatial working memory. Adrafinil antagonizes Prazosin (HY-B0193)-induced hypoactivity and hypothermia, exerts anticonvulsant effects, and induces sustained enhancement of high-frequency electrocortical activity. Adrafinil can be used for research on decreased alertness and specific cognitive deficits .
Referencia número: HY-W103463
No. CAS: 4641-57-0
Synonyms: 1-Phenylpyrrolidin-2-one
Target:
Áreas de investigación:
1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes .
Referencia número: HY-12688
No. CAS: 26647-82-5
Referencia número: HY-N7497
No. CAS: 20853-07-0
Target:
Referencia número: HY-B0188AR
No. CAS: 21535-47-7
Synonyms: Org GB 94 (Standard)
Referencia número: HY-B0188S
No. CAS: 81957-76-8
Synonyms: Mianserine-d3
Referencia número: HY-U00122
No. CAS: 76001-09-7
Target:
Áreas de investigación:
Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new agent development.
Referencia número: HY-B0188AS
No. CAS: 1219804-97-3
Synonyms: Org GB 94-d3
Referencia número: HY-147196
No. CAS: 2384184-42-1
KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12 NLS. KB03-SLF fails to degrade nuclear-localized FKBP12 NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12 NLS in a manner similar to KB02-SLF (HY-129610) .
Referencia número: HY-N7497R
No. CAS: 20853-07-0
Category:
Target:
Referencia número: HY-106489
No. CAS: 82168-26-1
Áreas de investigación:
Adafenoxate is a nootropic agent. Adafenoxate can improve Scopolamine (HY-N0296)-impaired memory, exploratory behavior and physical capabilities. Adafenoxate can be used for the research of neurological disease .
Referencia número: HY-106752
No. CAS: 98383-40-5
Synonyms: MRS-3310
Target:
Áreas de investigación:
CI-936 (MRS-3310) is an orally active A2 agonist with 25 nM affinity. CI-936 produces potent and selective effects in preclinical tests predictive of antipsychotic efficacy. CI-936 inhibits exploratory activity in mice .
Referencia número: HY-P0267A
No. CAS: 1036322-26-5
Target:
Áreas de investigación:
Referencia número: HY-184837
No. CAS: 53772-82-0
Target:
Áreas de investigación:
cis-Flupenthixol is an orally active dopamine receptor antagonist, with a Ki value of 1.4 nM for the Dopamine D-1 receptor and 0.74 nM for the Dopamine D-2 receptor. cis-Flupenthixol blocks dopamine receptors in the medial preoptic area and striatum, impairs male mating behavior, and reduces the concentrations of striatal dopamine metabolites. cis-Flupenthixol alters striatal acetylcholine concentrations in a time-dependent manner and enhances Apomorphine (HY-12723)-induced stereotyped behaviors. cis-Flupenthixol inhibits exploratory locomotor activity and triggers a compensatory increase in dopamine turnover in the striatum and limbic regions. cis-Flupenthixol can be used in studies related to tardive dyskinesia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
