53772-82-0
Chemical Structure
cis-Flupenthixol
- CAS No.: 53772-82-0
- Formula:C23H25F3N2OS
- Molecular Weight:434.52
InChIKey: NJMYODHXAKYRHW-DVZOWYKESA-N
SMILES: OCCN(CC1)CCN1CC/C=C2C3=CC(C(F)(F)F)=CC=C3SC4=CC=CC=C4\2
Biological Activity: cis-Flupenthixol is an orally active dopamine receptor antagonist, with a Ki value of 1.4 nM for the Dopamine D-1 receptor and 0.74 nM for the Dopamine D-2 receptor. cis-Flupenthixol blocks dopamine receptors in the medial preoptic area and striatum, impairs male mating behavior, and reduces the concentrations of striatal dopamine metabolites. cis-Flupenthixol alters striatal acetylcholine concentrations in a time-dependent manner and enhances Apomorphine (HY-12723)-induced stereotyped behaviors. cis-Flupenthixol inhibits exploratory locomotor activity and triggers a compensatory increase in dopamine turnover in the striatum and limbic regions. cis-Flupenthixol can be used in studies related to tardive dyskinesia[1][2][3].
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cis-Flupenthixol | cis-Flupenthixol is an orally active dopamine receptor antagonist, with a Ki value of 1.4 nM for the Dopamine D-1 receptor and 0.74 nM for the Dopamine D-2 receptor. cis-Flupenthixol blocks dopamine receptors in the medial preoptic area and striatum, impairs male mating behavior, and reduces the concentrations of striatal dopamine metabolites. cis-Flupenthixol alters striatal acetylcholine concentrations in a time-dependent manner and enhances Apomorphine (HY-12723)-induced stereotyped behaviors. cis-Flupenthixol inhibits exploratory locomotor activity and triggers a compensatory increase in dopamine turnover in the striatum and limbic regions. cis-Flupenthixol can be used in studies related to tardive dyskinesia. | |||||||||||||||||||||
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(E/Z)-Flupentixol dihydrochloride-d4 | (E/Z)-Flupentixol dihydrochloride-d4 is the deuterium labeled (E/Z)-Flupentixol dihydrochloride. | |||||||||||||||||||||
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- [1]. Pehek EA, et al. Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats. Brain research. 1988 Mar 08;443(1-2):70-6. [Content Brief]
- [2]. Murugaiah K, et al. Increased striatal acetylcholine after 14 months cis-flupenthixol treatment in rats suggests functional supersensitivity of dopamine receptors. Life sciences. 1982 Jul 12;31(2):181-8. [Content Brief]
- [3]. Ahlenius S, et al. Suppression of exploratory locomotor activity and increase in dopamine turnover following the local application of cis-flupenthixol into limbic projection areas of the rat striatum. Brain research. 1987 Jan 27;402(1):131-8. [Content Brief]
