4641-57-0
Chemical Structure
1-Phenyl-2-pyrrolidinone
Synonym(s): 1-Phenylpyrrolidin-2-one
- CAS. Nr.: 4641-57-0
- Formula:C10H11NO
- Molecular Weight:161.20
IUPAC Name: 1-phenylpyrrolidin-2-one
InChIKey: JMVIVASFFKKFQK-UHFFFAOYSA-N
SMILES: C1=CC=C(C=C1)N2CCCC2=O
Biological Activity: 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes[1][2].
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1-Phenyl-2-pyrrolidinone | 99.86% | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes. | ||||||||||||||||||||
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- [1]. Patkina N, et al. Some psychotropic effects of phenibut and phenylpyrrolidone. Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta (1979), 31(3), 63-6.
- [2]. Kovalev GV, et al. Effect of γ-aminobutyric acid derivatives on baroreceptor reflexes in nonanesthetized animals. Russian. 1980, (VINITI 1311-80), 10 pp.
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