63547-13-7
Chemical Structure
Adrafinil
Synonym(s): CRL 40028
- CAS No.: 63547-13-7
- Formula:C15H15NO3S
- Molecular Weight:289.35
IUPAC Name: 2-(benzhydrylsulfinyl)-N-hydroxyacetamide
InChIKey: CGNMLOKEMNBUAI-UHFFFAOYSA-N
SMILES: O=C(NO)CS(C(C1=CC=CC=C1)C2=CC=CC=C2)=O
Biological Activity: Adrafinil (CRL 40028) is an orally active vigilance promoting agent. Adrafinil enhances central noradrenergic transmission, improves spontaneous activity, exploratory behavior, discriminative learning ability and response motivation, but impairs visuospatial working memory. Adrafinil antagonizes Prazosin (HY-B0193)-induced hypoactivity and hypothermia, exerts anticonvulsant effects, and induces sustained enhancement of high-frequency electrocortical activity. Adrafinil can be used for research on decreased alertness and specific cognitive deficits[1][2][3][4].
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Adrafinil | 99.59% | Adrafinil (CRL 40028) is an orally active vigilance promoting agent. Adrafinil enhances central noradrenergic transmission, improves spontaneous activity, exploratory behavior, discriminative learning ability and response motivation, but impairs visuospatial working memory. Adrafinil antagonizes Prazosin (HY-B0193)-induced hypoactivity and hypothermia, exerts anticonvulsant effects, and induces sustained enhancement of high-frequency electrocortical activity. Adrafinil can be used for research on decreased alertness and specific cognitive deficits. | ||||||||||||||||||||
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- [1]. Milgram NW, et al. Oral administration of adrafinil improves discrimination learning in aged beagle dogs. Pharmacol Biochem Behav. 2000;66(2):301-305. [Content Brief]
- [2]. Siwak CT, et al. Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs. Pharmacol Biochem Behav. 2003;76(1):161-168. [Content Brief]
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[3]. Simon P, et al. Pharmacological evidence of the stimulation of central alpha-adrenergic receptors. Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):183-6.
[Content Brief] - [4]. Siwak CT, et al. Adrafinil: effects on behavior and cognition in aged canines. Prog Neuropsychopharmacol Biol Psychiatry. 2000;24(5):709-726. [Content Brief]
Keywords
