Nlgn4l - neuroligin 4-like Gene

Also Known as NL4; NL-4; Nlgn4; Nlgn4x

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100113365

Summary

Predicted to enable several functions, including chloride ion binding activity; neurexin family protein binding activity; and protein homodimerization activity. Involved in several processes, including brainstem development; male courtship behavior; and territorial aggressive behavior. Acts upstream of or within social behavior. Located in glycinergic synapse and plasma membrane. Is integral component of postsynaptic specialization membrane. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN4X (neuroligin 4 X-linked) and NLGN4Y (neuroligin 4 Y-linked). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn4l Products (7)

mRNA Protein Name
XM_036162148.1 XP_036018041.1 neuroligin 4-like isoform X2
XM_036162147.1 XP_036018040.1 neuroligin 4-like isoform X1
XM_036162149.1 XP_036018042.1 neuroligin 4-like isoform X3
XM_036162145.1 XP_036018038.1 neuroligin 4-like isoform X1
XM_036162146.1 XP_036018039.1 neuroligin 4-like isoform X1
XM_036162151.1 XP_036018044.1 neuroligin 4-like isoform X5
XM_036162150.1 XP_036018043.1 neuroligin 4-like isoform X4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in brainstem development IMP
IMP: Inferred from mutant phenotype
18227507 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
18227507 MGI
involved in male courtship behavior IMP
IMP: Inferred from mutant phenotype
18227507 MGI
involved in organ growth IMP
IMP: Inferred from mutant phenotype
18227507 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
18227507 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
18227507 MGI
involved in territorial aggressive behavior IMP
IMP: Inferred from mutant phenotype
18227507 MGI
involved in vocalization behavior IMP
IMP: Inferred from mutant phenotype
18227507 MGI
Cellular Component GO Annotation Evidence References Source
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
21282647 MGI
is active in glycinergic synapse IMP
IMP: Inferred from mutant phenotype
21282647 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18227507 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
21282647 MGI
is active in postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
21282647 MGI
located in synapse IDA
IDA: Inferred from direct assay
18227507 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroligin 4-like

  • neural cell adhesion protein neuroligin 4

  • neuroligin 4, X-linked

  • neurologin-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09342 NLGN4X Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09343 NLGN4Y Human Pre-designed siRNA Set A Pre-designed Set / Unkown