TMEM170B - transmembrane protein 170B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 100113407

About TMEM170B

This gene has 1 transcript (splice variant), 200 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 11.1), brain (RPKM 9.1) and 21 other tissues.

Summary

Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM170B Products (1)

mRNA Protein Name
NM_001100829.3 NP_001094299.1 transmembrane protein 170B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29367600 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
29367600 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
29367600 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM170B Protein Structure

Tmemb_170

Tmemb_170: Putative transmembrane protein 170 (29 - 132)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

transmembrane protein 170B

Related Diseases

Diseases Alias
Orofacial Cleft 1

  • OFC1

  • Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1

  • Orofacial Cleft, Nonsyndromic

  • Ofc

  • Cleft Lip/Palate, Nonsyndromic

  • Orofacial Cleft-1

  • Nonsyndromic Cleft Lip With Or Without Cleft Palate 1

  • Nonsyndromic Cleft Lip Palate

  • Otofaciocervical Syndrome 1
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14681 TMEM170B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMEM170B MGD MGI:3647046
Felis catus TMEM170B VGNC VGNC:102537
Rattus norvegicus TMEM170B RGD RGD:1561506
Macaca mulatta TMEM170B VGNC VGNC:104435
Canis familiaris TMEM170B VGNC VGNC:54375
Bos taurus TMEM170B VGNC VGNC:54241