2. Gene
  3. PLA2G4B - phospholipase A2 group IVB Gene

PLA2G4B - phospholipase A2 group IVB Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HsT16992; cPLA2-beta

Gene ID: 100137049 | Gene type: protein coding

About PLA2G4B

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,838,847-41,848,143 (from NCBI)

This gene has 6 transcripts (splice variants), 149 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 29.6), esophagus (RPKM 11.9) and 23 other tissues.

Summary

This gene encodes a member of the cytosolic Phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of Phospholipids, releasing lysophospholipids and fatty acids. This Enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic Phospholipase A2 domains. [provided by RefSeq, Jul 2008]

PLA2G4B Products(1)

mRNA Protein Name
NM_001114633.2 NP_001108105.1 cytosolic phospholipase A2 beta

PLA2G4B Protein Structure

C2

C2: C2 domain (12 - 91)

PLA2_B

PLA2_B: Lysophospholipase catalytic domain (297 - 503)

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  • 781 a.a.
Protein Preferred Names Protein Names

cytosolic phospholipase A2 beta

lysophospholipase A1 group IVB

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 12

IBD12
Inflammatory Bowel Disease 17

Inflammatory Bowel Disease 17, Protection Against

IBD17

Bowel Disease, Inflammatory, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10627 PLA2G4B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA2G4B RGD RGD:1308658
Mus musculus PLA2G4B MGD MGI:2384819