2. Gene
  3. Mir21 - microRNA 21 Gene

Mir21 - microRNA 21 Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rno-mir-21

Gene ID: 100314000 | Gene type: ncRNA

About Mir21

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
32040481 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
30847937 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
19336275 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
30542412 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
27798620 RGD
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
30680008 RGD
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
28880208 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
30680008 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19336275 RGD
involved in negative regulation of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
29084974 RGD
involved in negative regulation of hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
29187695 RGD
involved in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
IMP: Inferred from mutant phenotype
19336275 RGD
involved in negative regulation of myofibroblast cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19043405 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
25484256 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20840605 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
30680008 RGD
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
29084974 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
29084974 RGD
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
31759996 RGD
involved in positive regulation of endothelial tube morphogenesis IMP
IMP: Inferred from mutant phenotype
31759996 RGD
involved in positive regulation of myofibroblast differentiation IMP
IMP: Inferred from mutant phenotype
27798620 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
31759996 RGD
involved in positive regulation of wound healing IMP
IMP: Inferred from mutant phenotype
27798620 RGD
involved in regulation of mesenchymal stem cell differentiation IMP
IMP: Inferred from mutant phenotype
27798620 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
31959353 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular vesicle IDA
IDA: Inferred from direct assay
31102912 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00449 hsa-miR-21-5p mimic 99.49% Unkown
HY-RI00449 hsa-miR-21-5p inhibitor 99.18% Unkown
HY-RI00449A hsa-miR-21-5p antagomir 99.28% Unkown
HY-139682 Dovitinib-RIBOTAC Modulator 99.31% Unkown
HY-139682A Dovitinib-RIBOTAC TFA Modulator 98.35% Unkown
HY-R00449A hsa-miR-21-5p agomir 99.74% Unkown
HY-153534 microRNA-21-IN-3 Inhibitor 98.68% Unkown
HY-151516 microRNA-21-IN-2 Inhibitor 99.45% Unkown
HY-170791 CIB-L43 99.71% Unkown
HY-130487 miR-21-IN-2 Inhibitor 98.42% Unkown
HY-R00444 hsa-miR-21-3p mimic 98.15% Unkown
HY-RI00444 hsa-miR-21-3p inhibitor 95.63% Unkown
HY-164054 MicroRNA modulator-2 Modulator 99.54% Unkown
HY-R00444A hsa-miR-21-3p agomir 93.66% Unkown
HY-R02843 mmu-miR-21b mimic 98.83% Unkown
HY-RI02842A mmu-miR-21a-3p antagomir 93.25% Unkown
HY-RI02843 mmu-miR-21b inhibitor 97.01% Unkown
HY-143208 HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt / Unkown
HY-179344 Benzazepinoquinoline-spermine Inhibitor / Unkown
HY-R02842 mmu-miR-21a-3p mimic / Unkown
HY-R02842A mmu-miR-21a-3p agomir / Unkown
HY-R02843A mmu-miR-21b agomir / Unkown
HY-R02844 mmu-miR-21c mimic / Unkown
HY-R02844A mmu-miR-21c agomir / Unkown
HY-RI00444A hsa-miR-21-3p antagomir / Unkown
HY-RI02842 mmu-miR-21a-3p inhibitor / Unkown
HY-RI02843A mmu-miR-21b antagomir / Unkown
HY-RI02844 mmu-miR-21c inhibitor / Unkown
HY-RI02844A mmu-miR-21c antagomir / Unkown
HY-164053 miR-21-IN-3 Inhibitor 99.58% Unkown
HY-R04615 mmu-miR-21a-5p mimic 99.41% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir21 NCBI NCBI:406991