MIR21 - microRNA 21 Gene
Also Known as MIRN21; miR-21; miRNA21; hsa-mir-21
Species: Homo sapiens
About MIR21
This gene has 1 transcript (splice variant) and 105 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
19578724 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
16762633 | GOA |
| enables mRNA base-pairing translational repressor activity |
IMP
IMP: Inferred from mutant phenotype
|
18372920 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
23657402 | GOA |
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
28159509 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
26646931 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Glioblastoma |
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| Oral Squamous Cell Carcinoma |
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| Glioma |
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| Larynx Cancer |
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| Cholesteatoma Of Middle Ear |
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| Cholangiocarcinoma |
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| Pancreatic Ductal Adenocarcinoma |
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| Vascular Disease |
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| Head And Neck Cancer |
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| Tongue Squamous Cell Carcinoma |
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| Cervical Cancer |
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| Small Cell Cancer Of The Lung |
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| Microvascular Complications Of Diabetes 3 |
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| Squamous Cell Carcinoma, Head And Neck |
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| Esophageal Cancer |
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| Bladder Cancer |
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| Glioma Susceptibility 1 |
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| Pancreatic Cancer |
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| Hepatocellular Carcinoma |
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| Gastric Cancer |
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| Prostate Cancer |
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| Cowden Syndrome |
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| Lung Cancer |
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| Heart Disease |
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| Laryngeal Squamous Cell Carcinoma |
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| Breast Cancer |
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| Hepatitis B |
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| Colorectal Cancer |
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| Dermatomyositis |
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| Esophagus Adenocarcinoma |
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| Ovarian Serous Carcinoma |
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| Polymyositis |
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| Non-Alcoholic Fatty Liver Disease |
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| Psoriasis |
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| Leiomyoma, Uterine |
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| Pulmonary Hypertension |
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| Lymphoma, Hodgkin, Classic |
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| Muscular Dystrophy, Duchenne Type |
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| Inclusion Body Myositis |
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| Miyoshi Muscular Dystrophy 1 |
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| Kidney Cancer |
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| Facioscapulohumeral Muscular Dystrophy 1 |
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| Myocardial Infarction |
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| Diffuse Large B-Cell Lymphoma |
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| Lip And Oral Cavity Cancer |
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| Leukemia, Acute Lymphoblastic |
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| Autism Spectrum Disorder |
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| Oral Cavity Cancer |
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| Malignant Exocrine Pancreas Neoplasm |
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| Cell Type Benign Neoplasm |
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| Leukemia, Chronic Lymphocytic |
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| Mastitis |
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| Laryngeal Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Bile Duct Adenocarcinoma |
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| Endocrine System Disease |
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| Thoracic Cancer |
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| Large Intestine Cancer |
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| Arteriosclerosis Obliterans |
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| Oral Submucous Fibrosis |
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| Connective Tissue Cancer |
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| Renal Cell Carcinoma, Nonpapillary |
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| Leukemia, Acute Myeloid |
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| Cervix Disease |
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| Ovarian Cancer |
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| Ovary Epithelial Cancer |
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| Reproductive System Disease |
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| Female Reproductive System Disease |
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| Intrinsic Cardiomyopathy |
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| Esophageal Disease |
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| Central Nervous System Cancer |
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| Gastrointestinal System Disease |
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| Peripartum Cardiomyopathy |
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| Bile Duct Disease |
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| Colonic Disease |
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| Gastrointestinal System Benign Neoplasm |
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| Respiratory System Cancer |
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| Bile Duct Cancer |
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| Arteries, Anomalies Of |
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| Systemic Scleroderma |
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| Extrinsic Cardiomyopathy |
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| Autoimmune Pancreatitis |
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| Upper Respiratory Tract Disease |
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| Urethral Stricture |
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| Male Reproductive Organ Cancer |
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| Glucose Metabolism Disease |
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| Spinal Disease |
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| Ovarian Disease |
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| Gastrointestinal System Cancer |
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| Stomach Disease |
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| Urinary System Disease |
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| Limb Ischemia |
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| Respiratory System Disease |
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| Male Reproductive System Disease |
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| Carbohydrate Metabolic Disorder |
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| Acquired Metabolic Disease |
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| Intestinal Disease |
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| Colorectal Adenoma |
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| Nasopharyngeal Disease |
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| Bone Marrow Cancer |
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| Inherited Metabolic Disorder |
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| Biliary Tract Disease |
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| Pharynx Cancer |
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| Sensory System Disease |
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| Uterine Anomalies |
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| Intestinal Benign Neoplasm |
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| Malignant Astrocytoma |
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| Autoimmune Disease Of Gastrointestinal Tract |
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| Immune System Disease |
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| Endocrine Gland Cancer |
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| Granulomatous Mastitis |
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| Cervicitis |
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| Lipid Storage Disease |
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| Skin Carcinoma |
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| Bone Cancer |
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| Integumentary System Disease |
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| Arteriosclerosis |
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| Pancreas Disease |
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| Leukocyte Disease |
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| Non-Alcoholic Steatohepatitis |
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| Endocrine Organ Benign Neoplasm |
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| Autoimmune Disease Of Musculoskeletal System |
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| Lymphatic System Disease |
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| Tongue Disease |
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| Lymphatic System Cancer |
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| Aortic Disease |
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| Oropharynx Cancer |
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| Heart Valve Disease |
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| Human Papillomavirus Infectious Disease |
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| Bronchial Disease |
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| Ischemic Bone Disease |
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| Cervix Carcinoma |
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| Peripheral Artery Disease |
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| Bladder Disease |
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| Autonomic Nervous System Neoplasm |
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| Bone Inflammation Disease |
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| Peripheral Nervous System Neoplasm |
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| Central Nervous System Benign Neoplasm |
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| Low Grade Glioma |
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| Pleural Cancer |
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| Fatty Liver Disease |
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| Mature T-Cell And Nk-Cell Lymphoma |
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| Retinal Cancer |
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Aortic Aneurysm |
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| Periodontitis |
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| Complex Regional Pain Syndrome |
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| Overnutrition |
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| Tongue Carcinoma |
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| Pleural Disease |
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| Retinal Vascular Disease |
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| Aortic Valve Disease 2 |
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| Disease By Infectious Agent |
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| Cystic Echinococcosis |
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| Heart Conduction Disease |
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| Decubitus Ulcer |
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| Rete Ovarii Adenocarcinoma |
|
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| Hypertrophy Of Breast |
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| Ischemia |
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| Central Nervous System Disease |
|
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| Atrial Fibrillation |
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| Pancreatitis |
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| Retinal Disease |
|
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| Disease Of Mental Health |
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| Mitral Valve Disease |
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| Pulmonary Fibrosis |
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| Breast Disease |
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| Coronary Stenosis |
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| Muscular Disease |
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| Parasitic Helminthiasis Infectious Disease |
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| Coronavirus Infectious Disease |
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| Prostate Disease |
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| Alport Syndrome |
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| Intermediate Coronary Syndrome |
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| Physical Disorder |
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| Autoimmune Disease Of Endocrine System |
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| Primary Bacterial Infectious Disease |
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| Biliary Tract Cancer |
|
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| Autoimmune Disease Of Central Nervous System |
|
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| Ocular Cancer |
|
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| Pancreatic Cystadenoma |
|
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| Growth Hormone Secreting Pituitary Adenoma |
|
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| Nasopharyngeal Carcinoma |
|
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| Liver Disease |
|
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| Serous Cystadenocarcinoma |
|
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| Papillary Adenocarcinoma |
|
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| Bone Deterioration Disease |
|
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| Respiratory Allergy |
|
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| Rectum Cancer |
|
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| Autonomic Nervous System Disease |
|
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| Ovarian Clear Cell Carcinoma |
|
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| Hematologic Cancer |
|
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| Muscle Tissue Disease |
|
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| Contact Dermatitis |
|
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| Esophagitis, Eosinophilic, 1 |
|
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| Skin Squamous Cell Carcinoma |
|
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| Microvascular Complications Of Diabetes 5 |
|
|
| Renal Fibrosis |
|
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| Cerebrovascular Disease |
|
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| Aortic Aneurysm, Familial Abdominal, 1 |
|
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| Brain Cancer |
|
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| Peripheral Nervous System Disease |
|
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| Chronic Ulcer Of Skin |
|
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| Colitis |
|
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| Chromosomal Disease |
|
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| Toxoplasmosis |
|
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| Avian Influenza |
|
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| Hypertension, Essential |
|
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| Connective Tissue Disease |
|
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| Cardiovascular System Disease |
|
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| Mouth Disease |
|
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| Lymphoma, Non-Hodgkin, Familial |
|
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| Interstitial Lung Disease |
|
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| Lysosomal Storage Disease |
|
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| Melanoma In Congenital Melanocytic Nevus |
|
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
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| Chromosomal Deletion Syndrome |
|
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| Allergic Contact Dermatitis |
|
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| Burkitt Lymphoma |
|
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| Diabetes Mellitus |
|
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| Neuroblastoma |
|
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| Bone Disease |
|
|
| Peripheral T-Cell Lymphoma |
|
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| Lung Disease |
|
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| Focal Epilepsy |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Demyelinating Disease |
|
|
| Interstitial Lung Disease 2 |
|
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| Persistent Fetal Circulation Syndrome |
|
|
| High Grade Glioma |
|
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| Crohn'S Disease |
|
|
| Prion Disease |
|
|
| Nervous System Disease |
|
|
| Aortic Valve Disease 1 |
|
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| Cystadenocarcinoma |
|
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| Pulmonary Disease, Chronic Obstructive |
|
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| Asthma |
|
|
| Allergic Disease |
|
|
| Multiple Sclerosis |
|
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| Viral Infectious Disease |
|
|
| Lipoprotein Quantitative Trait Locus |
|
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| Endometrial Cancer |
|
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| Adult Respiratory Distress Syndrome |
|
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| Eye Disease |
|
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| Specific Developmental Disorder |
|
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| Prediabetes Syndrome |
|
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| Immune Deficiency Disease |
|
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| Lipid Metabolism Disorder |
|
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| Mycobacterium Tuberculosis 1 |
|
|
| Severe Covid-19 |
|
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| Skin Disease |
|
|
| Skin Melanoma |
|
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| Respiratory Failure |
|
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| Bacterial Infectious Disease |
|
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| Osteoporosis |
|
|
| Melanoma |
|
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| Multiple Endocrine Neoplasia, Type I |
|
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| Chronic Kidney Disease |
|
|
| Psychotic Disorder |
|
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| Hypertrophic Cardiomyopathy |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Stroke, Ischemic |
|
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| Dilated Cardiomyopathy |
|
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| Dermatitis, Atopic |
|
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| Myeloma, Multiple |
|
|
| Thrombocytopenia |
|
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| Systemic Lupus Erythematosus |
|
|
| Arrhythmogenic Right Ventricular Cardiomyopathy |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Colonic Benign Neoplasm |
|
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| Myopathy |
|
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| Aortic Aneurysm, Familial Thoracic 1 |
|
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| Retinitis Pigmentosa |
|
|