CDH7 - cadherin 7 Gene

Homo sapiens

Also known as CDH7L1

Gene ID: 1005 | Gene type: protein coding

About CDH7

Cytogenetic location: 18q22.1 Genomic coordinates (GRCh38): 18:65,750,252-65,890,337 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues and 33 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) Cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I Cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]

CDH7 Products(4)

mRNA	Protein	Name
NM_001317214.3	NP_001304143.1	cadherin-7 isoform 2 precursor
NM_001362438.2	NP_001349367.1	cadherin-7 isoform 1 preproprotein
NM_004361.5	NP_004352.2	cadherin-7 isoform 1 preproprotein
NM_033646.4	NP_387450.1	cadherin-7 isoform 1 preproprotein

CDH7 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
785 a.a.

Protein Preferred Names

Protein Names

cadherin-7

cadherin 7, type 2

Related Diseases

Diseases

Alias

Craniofacial-Deafness-Hand Syndrome

CDHS	Craniofacial Deafness Hand Syndrome
Sommer-Young-Wee-Frye Syndrome	Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss
Craniofacial-Hearing Loss-Hand Syndrome

Choanal Atresia, Posterior

Choanal Atresia	Atresia Of Nares
Posterior Choanal Atresia	PCA
Imperforate Nares	Choanal Fusion
Congenital Stenosis Of Nares	Congenital Stenosis Of Choanae
Nasal Atresia Nos

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Waardenburg Syndrome, Type 2d

Waardenburg Syndrome Type 2d	WS2D
Waardenburg Syndrome, Type Iid	Waardenburg Syndrome Type Iid
Waardenburg Syndrome 2d

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02340	CDH7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDH7	MGD	MGI:2442792
Bos taurus	CDH7	VGNC	VGNC:27106
Rattus norvegicus	CDH7	RGD	RGD:1306856
Felis catus	CDH7	VGNC	VGNC:60686
Canis familiaris	CDH7	VGNC	VGNC:39034
Macaca mulatta	CDH7	VGNC	VGNC:70975
Others	CDH7	NCBI