SLC17A4 - solute carrier family 17 member 4 Gene

Homo sapiens

Also known as KAIA2138

Gene ID: 10050 | Gene type: protein coding

About SLC17A4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:25,754,699-25,781,199 (from NCBI)

This gene has 3 transcripts (splice variants), 400 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 10.3), duodenum (RPKM 9.0) and 5 other tissues.

Summary

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

SLC17A4 Products(2)

mRNA	Protein	Name
NM_001286121.1	NP_001273050.1	probable small intestine urate exporter isoform b
NM_005495.3	NP_005486.1	probable small intestine urate exporter isoform a

SLC17A4 Protein Structure

MFS_1

0
100
200
300
400
497 a.a.

Protein Preferred Names

Protein Names

probable small intestine urate exporter

Na/PO4 cotransporter

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13037	SLC17A4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC17A4	MGD	MGI:2442850
Felis catus	SLC17A4	VGNC	VGNC:65220
Bos taurus	SLC17A4	VGNC	VGNC:34699
Rattus norvegicus	SLC17A4	RGD	RGD:1584758
Canis familiaris	SLC17A4	VGNC	VGNC:59140
Macaca mulatta	SLC17A4	VGNC	VGNC:77404

Name
Email *

	Sorry, but the email address you supplied was invalid.