SLC17A4 - solute carrier family 17 member 4 Gene

Also Known as KAIA2138

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10050

About SLC17A4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:25,754,699-25,781,199 (from NCBI)

This gene has 3 transcripts (splice variants), 400 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 10.3), duodenum (RPKM 9.0) and 5 other tissues.

Summary

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]

SLC17A4 Products (2)

mRNA Protein Name
NM_001286121.1 NP_001273050.1 probable small intestine urate exporter isoform b
NM_005495.3 NP_005486.1 probable small intestine urate exporter isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables thyroid hormone transmembrane transporter activity IDA
IDA: Inferred from direct assay
30367059 GOA
enables thyroid hormone transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
34937426 GOA
enables urate transmembrane transporter activity IDA
IDA: Inferred from direct assay
22460716 GOA
Biological Process GO Annotation Evidence References Source
involved in sodium-dependent phosphate transport IDA
IDA: Inferred from direct assay
22460716 GOA
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
22460716 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC17A4 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (45 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
Protein Preferred Names Protein Names

probable small intestine urate exporter

  • Na/PO4 cotransporter

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13037 SLC17A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC17A4 MGD MGI:2442850
Felis catus SLC17A4 VGNC VGNC:65220
Bos taurus SLC17A4 VGNC VGNC:34699
Rattus norvegicus SLC17A4 RGD RGD:1584758
Canis familiaris SLC17A4 VGNC VGNC:59140
Macaca mulatta SLC17A4 VGNC VGNC:77404
Others SLC17A4 NCBI