Rubcn - RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein Gene

Also Known as Rubicon; mKIAA0226; 5330403K09; 1700021K19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100502698

Summary

Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in negative regulation of autophagosome maturation; negative regulation of endocytosis; and negative regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within autophagy; endocytosis; and immune system process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in early endosome and late endosome. Is expressed in central nervous system and retina. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to human RUBCN (rubicon Autophagy regulator). [provided by Alliance of Genome Resources, Apr 2022]

Rubcn Products (3)

mRNA Protein Name
NM_001200038.1 NP_001186967.1 run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform a
NM_001374776.1 NP_001361705.1 run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform c
NM_172615.4 NP_766203.1 run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25594178 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

run domain Beclin-1-interacting and cysteine-rich domain-containing protein

  • run domain Beclin-1 interacting and cystein-rich containing protein

  • run domain Beclin-1 interacting and cysteine-rich containing protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12343 RUBCN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rubcn NCBI NCBI:9711