Klhl3 - kelch-like 3 Gene

Also Known as EG627648; 7530408C15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100503085

Summary

Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; distal tubule morphogenesis; and renal sodium ion absorption. Predicted to be located in cytoplasm and Cytoskeleton. Predicted to be part of Cul3-RING ubiquitin Ligase complex. Predicted to be active in cytosol. Is expressed in endocrine gland; genitourinary system; heart; lung; and nervous system. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Klhl3 Products (3)

mRNA Protein Name
NM_001362415.2 NP_001349344.2 kelch-like protein 3 isoform 1
NM_001368867.1 NP_001355796.1 kelch-like protein 3 isoform 2
NM_001368868.1 NP_001355797.1 kelch-like protein 3 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23576762 MGI
Biological Process GO Annotation Evidence References Source
involved in gene expression IGI
IGI: Inferred from genetic interaction
23576762 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
23576762 MGI
involved in metabolic process IMP
IMP: Inferred from mutant phenotype
24821705 MGI
involved in monoatomic ion homeostasis IMP
IMP: Inferred from mutant phenotype
23576762 MGI
involved in potassium ion homeostasis IMP
IMP: Inferred from mutant phenotype
24821705 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
23576762 MGI
involved in protein phosphorylation IGI
IGI: Inferred from genetic interaction
28743496 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24821705 MGI
involved in protein polyubiquitination IGI
IGI: Inferred from genetic interaction
23576762 MGI
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
23576762 MGI
involved in renal absorption IMP
IMP: Inferred from mutant phenotype
24821705 MGI
involved in renal sodium ion absorption IMP
IMP: Inferred from mutant phenotype
24821705 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24821705 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kelch-like protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07366 KLHL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klhl3 NCBI NCBI:26249