Klhl3 - kelch-like 3 Gene

Mus musculus

Also known as EG627648; 7530408C15Rik

Gene ID: 100503085 | Gene type: protein coding

About Klhl3

Summary

Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; distal tubule morphogenesis; and renal sodium ion absorption. Predicted to be located in cytoplasm and Cytoskeleton. Predicted to be part of Cul3-RING ubiquitin Ligase complex. Predicted to be active in cytosol. Is expressed in endocrine gland; genitourinary system; heart; lung; and nervous system. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Klhl3 Products(3)

mRNA	Protein	Name
NM_001362415.2	NP_001349344.2	kelch-like protein 3 isoform 1
NM_001368867.1	NP_001355796.1	kelch-like protein 3 isoform 2
NM_001368868.1	NP_001355797.1	kelch-like protein 3 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23576762	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in gene expression	IGI IGI: Inferred from genetic interaction	23576762	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	23576762	MGI
involved in metabolic process	IMP IMP: Inferred from mutant phenotype	24821705	MGI
involved in monoatomic ion homeostasis	IMP IMP: Inferred from mutant phenotype	23576762	MGI
involved in potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	24821705	MGI
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	23576762	MGI
involved in protein phosphorylation	IGI IGI: Inferred from genetic interaction	28743496	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24821705	MGI
involved in protein polyubiquitination	IGI IGI: Inferred from genetic interaction	23576762	MGI
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	23576762	MGI
involved in renal absorption	IMP IMP: Inferred from mutant phenotype	24821705	MGI
involved in renal sodium ion absorption	IMP IMP: Inferred from mutant phenotype	24821705	MGI
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24821705	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kelch-like protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07366	KLHL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klhl3	NCBI	NCBI:26249

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