H2-Ea - histocompatibility 2, class II antigen E alpha Gene

Also Known as Ia3; Ia-3; H-2Ea; H2-Ea-ps; I-Ealpha; E-alpha-f; MHC-H2-Ea

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100504404

Summary

This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011]

H2-Ea Products (1)

mRNA Protein Name
NM_010381.3 NP_034511.3 histocompatibility 2, class II antigen E alpha precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
11027433 MGI
acts upstream of or within immunoglobulin mediated immune response IDA
IDA: Inferred from direct assay
11714799 MGI
acts upstream of or within immunoglobulin mediated immune response IGI
IGI: Inferred from genetic interaction
11714799 MGI
acts upstream of or within positive regulation of immune response IDA
IDA: Inferred from direct assay
11714799 MGI
acts upstream of or within positive regulation of immune response IGI
IGI: Inferred from genetic interaction
11714799 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7679955 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histocompatibility 2, class II antigen E alpha

  • H-2 class II histocompatibility antigen, E-D alpha chain

  • H-2 class II histocompatibility antigen, E-K alpha chain

  • H-2 class II histocompatibility antigen, E-U alpha chain

  • H2-IE-alpha

  • I-E alpha MHC class II

  • MHC class II H2-E alpha chain

  • MHC class II