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Emilin1 - elastin microfibril interfacer 1 Gene

Also Known as gp115; EMILIN-1; 5830419M17Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 100952

Summary

Enables extracellular matrix constituent conferring elasticity and identical protein binding activity. Involved in several processes, including negative regulation of signal transduction; regulation of extracellular matrix organization; and regulation of gene expression. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; heart and pericardium; and musculoskeletal system. Orthologous to human EMILIN1 (elastin microfibril interfacer 1). [provided by Alliance of Genome Resources, Apr 2022]

Emilin1 Products (1)

mRNA	Protein	Name
NM_133918.2	NP_598679.1	EMILIN-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellular matrix constituent conferring elasticity	IMP IMP: Inferred from mutant phenotype	14701737	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	14701737	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16530041	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	21949412	MGI
involved in elastic fiber assembly	IMP IMP: Inferred from mutant phenotype	25056700	MGI
acts upstream of or within extracellular matrix organization	IDA IDA: Inferred from direct assay	18757743	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of cell activation	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of collagen fibril organization	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of macrophage migration	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in negative regulation of vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	25056700	MGI
acts upstream of or within positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	18757743	MGI
involved in positive regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25056700	MGI
involved in regulation of blood pressure	IDA IDA: Inferred from direct assay	22814752	MGI
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21949412	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	14701737	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
EMILIN-1	elastin microfibril interface located protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04350	EMILIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Emilin1	NCBI	NCBI:11117