2. Gene
  3. Brk1 - BRICK1, SCAR/WAVE actin-nucleating complex subunit Gene

Brk1 - BRICK1, SCAR/WAVE actin-nucleating complex subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 6720456B07Rik

Gene ID: 101314 | Gene type: protein coding

About Brk1

Summary

Predicted to enable identical protein binding activity. Predicted to contribute to small GTPase binding activity. Acts upstream of or within several processes, including actin Cytoskeleton organization; in utero embryonic development; and positive regulation of cell population proliferation. Located in lamellipodium. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and nervous system. Orthologous to human BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex). [provided by Alliance of Genome Resources, Apr 2022]

Brk1 Products(1)

mRNA Protein Name
NM_133937.1 NP_598698.1 protein BRICK1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20861187 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
20861187 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20861187 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
20861187 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20861187 MGI
Cellular Component GO Annotation Evidence Reference Source
located in lamellipodium IDA
IDA: Inferred from direct assay
18560548 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein BRICK1

probable protein BRICK1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01625 BRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brk1 NCBI NCBI:55845